UniProt A0A024RAV5
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b (A0A024RAV5)
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b (UniProt A0A024RAV5): 4 experimental structures on GenesisL1, 6 ligands bound, 6 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A024RAV5
- Protein
- V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b
- Experimental structures
- 4
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 6 · 2 records with a druggable one
Structures
4 records of A0A024RAV5 in the MolNFT archive: 4 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6T5U | KRASG12C ligand complex | x-ray diffraction | A, B | MG, GDP, MKW | — |
| 7O83 | KRasG12C ligand complex | x-ray diffraction | A, B | MG, GDP, V52, CA | 1 (best 0.83) |
| 7O83 | KRASG12C ligand complex | x-ray diffraction | A, B | MG, GDP, V52, CA | — |
| 8PI0 | NMR2 Structure of KRAS G12V (GMPPNP bound) in complex with 5-(1H-indol-2-l)piperazin-2-one | solution nmr | A | YVW | 5 (best 0.78) |
Ligands
- GDP · Guanosine-5'-diphosphate · in 3 records
- MG · Magnesium ion · in 3 records
- CA · Calcium ion · in 2 records
- V52 · 1-[(7S)-11-chloro-12-(5-methyl-1H-indazol-4-yl)-9-oxa-2,5,15,17-tetrazatetracyclo[8.7.1.02,7.014, 18]octadeca-1(17),10,12,14(18),15-pentaen-5-yl]prop-2-en-1-one · in 2 records
- MKW · 1-[(7R)-16-chloro-15-(5-methyl-1H-indazol-4-yl)-9-oxa-2,5,12-triazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),11,13,15,17-pentaen-5-yl]prop-2-en-1-one · in 1 record
- YVW · (5~{S})-5-(1~{H}-indol-2-yl)piperazin-2-one · in 1 record
Elsewhere
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