Ligand · MKW

MKW · 1-[(7R)-16-chloro-15-(5-methyl-1H-indazol-4-yl)-9-oxa-2,5,12-triazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),11,13,15,17-pentaen-5-yl]prop-2-en-1-one

MKW, 1-[(7R)-16-chloro-15-(5-methyl-1H-indazol-4-yl)-9-oxa-2,5,12-triazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),11,13,15,17-pentaen-5-yl]prop-2-en-1-one (C25 H24 Cl N5 O2, 461.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component: MKW
Formula: C25 H24 Cl N5 O2
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

MKW in 2 structures; the first of them:

6T5U · KRasG12C ligand complex · MKW A203 · binds VAL9, GLY10, ALA11, CYS12, GLY13, LYS16, PRO34, THR58 and 16 more
6T5U · KRASG12C ligand complex · MKW A203 · binds GLY10, CYS12, LYS16, PRO34, ALA59, GLY60, GLN61, GLU62 and 10 more

Residues it binds most

GLY 4, ARG 4, GLN 4, GLU 4, TYR 4, ALA 4, ASP 4, CYS 4, HIS 4, LYS 4 (residue and the binding sites it lines).

Found with

GDP · Guanosine-5'-diphosphate
MG · Magnesium ion

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