J6R · (2S,4R)-5-(4-fluorophenyl)-2-methyl-4-[[2-[(1R,3R)-4-methyl-3-[5-methylhexyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-1-oxidanyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]pentanoic acid

Binding sites

J6R in 2 structures; the first of them:

• 7EN3 · Crystal structure of tubulin in complex with Tubulysin analogue TGL · J6R B505 · binds GLN11, GLN15, PRO173, LYS174, VAL175, SER176, ASP177, TYR208 and 17 more
• 7EN3 · Crystal structure of tubulin in complex with tubulysin analogue tgl · J6R B505 · binds GLN11, GLN15, PRO173, LYS174, VAL175, SER176, ASP177, TYR208 and 17 more

Residues it binds most

PRO 4, VAL 4, GLN 4, TYR 4, ASP 4, LEU 4, ARG 4, ASN 2, GLY 4, ILE 2 (residue and the binding sites it lines).

Found with

• ACP · Phosphomethylphosphonic acid adenylate ester
• GDP · Guanosine-5'-diphosphate
• GTP · Guanosine-5'-triphosphate
• CA · Calcium ion
• MG · Magnesium ion
• MES · 2-(N-morpholino)-ethanesulfonic acid