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Ligand · HV0

HV0 · 5-methoxy-2-methyl-~{N}-[[4-[4-[4-(trifluoromethyloxy) phenyl]piperidin-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide

HV0, 5-methoxy-2-methyl-~{N}-[[4-[4-[4-(trifluoromethyloxy) phenyl]piperidin-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide (C29 H29 F3 N4 O3, 538.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
HV0
Formula
C29 H29 F3 N4 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

HV0 in 2 structures; the first of them:

  • 7E1X · Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium… · HV0 N609 · binds PHE158, TYR161, TYR164, LEU171, GLY175, ALA178, ALA179, LEU180 and 13 more
  • 7E1X · Cryo-EM structure of hybrid respiratory supercomplex consisting of mycobacterium… · HV0 N609 · binds TYR161, LEU171, GLY175, ALA179, LEU180, THR184, MET187, LEU194 and 7 more

Residues it binds most

LEU 4, MET 4, THR 4, ALA 4, TYR 4, GLN 4, GLU 4, GLY 4, HIS 4, PRO 4 (residue and the binding sites it lines).

Found with

  • 9Y0 · (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate
  • 9YF · (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1r,2r,3r,4r, 5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate
  • CDL · Cardiolipin
  • FES · Fe2/s2 (inorganic) cluster
  • HEA · Heme-A
  • HEC · Heme C
  • HEM · Protoporphyrin IX containing Fe
  • MQ9 · Menaquinone-9
  • PLM · Palmitic acid
  • CU · Copper (II) ion

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