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Ligand · HFP

HFP · Alpha-hydroxyfarnesylphosphonic acid

HFP, Alpha-hydroxyfarnesylphosphonic acid (C15 H33 O4 P, 308.4 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
HFP
Formula
C15 H33 O4 P
Class
ligand
Structures
6
PDB entries
6

Binding sites

HFP in 6 structures; the first of them:

  • 1N94 · Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and… · HFP A501 · binds LYS164, TYR166, LYS198, ASN199, TYR200, HIS201, ARG202, TYR205 and 8 more
  • 1N95 · Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and… · HFP B501 · binds LYS164, TYR166, TYR200, HIS201, TRP102, ARG202, TYR205, HIS248 and 8 more
  • 1N9A · Farnesyltransferase complex with tetrahydropyridine inhibitors · HFP B501 · binds LYS164, TYR166, TYR200, HIS201, TRP102, ARG202, TYR205, HIS248 and 8 more
  • 1NI1 · Imidazole and cyanophenyl farnesyl transferase inhibitors · HFP B501 · binds LYS164, TYR166, TYR200, HIS201, TRP102, TYR154, ARG202, TYR205 and 10 more
  • 1NL4 · Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor · HFP B501 · binds LYS164, TYR166, TYR200, HIS201, TRP102, TYR154, ARG202, TYR205 and 10 more
  • 1QBQ · Structure of rat farnesyl protein transferase complexed with a cvim peptide and… · HFP B2001 · binds LYS164, TYR166, TYR200, HIS201, TRP102, TYR154, ARG202, TYR205 and 11 more

Residues it binds most

TYR 6, ARG 6, HIS 6, LYS 6, TRP 6, CYS 6, GLY 6, ASN 1, ILE 1, VAL 1 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • 2C5 · 2-chloro-5-(3-chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)- methoxymethyl]-nicotinonitrile
  • FTH · 1-[2-(4-cyano-benzylamino)-3-(3-methyl-3H-imidazol-4-yl)-propionyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile
  • FTI · 1-{2-[3-(4-cyano-benzyl)-3H-imidazol-4-yl]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile
  • FTL · 4-[(3-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
  • TIN · 2-{(5-{[butyl-(2-cyclohexyl-ethyl)-amino]-methyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid
  • ACT · Acetate ion

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