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Ligand · FTH

FTH · 1-[2-(4-cyano-benzylamino)-3-(3-methyl-3H-imidazol-4-yl)-propionyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile

FTH, 1-[2-(4-cyano-benzylamino)-3-(3-methyl-3H-imidazol-4-yl)-propionyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile (C31 H28 N6 O, 500.6 g/mol), in the MolNFT structures on GenesisL1: bound in 1 record (1 PDB entry).…

Component
FTH
Formula
C31 H28 N6 O
Class
ligand
Structures
1
PDB entries
1

Binding sites

FTH in 1 structure; the first of them:

  • 1N95 · Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and… · FTH B1001 · binds TYR166, TYR93, LEU96, SER99, TRP102, LEU103, TRP106, ARG202 and 7 more

Residues it binds most

ASP 1, TRP 1, TYR 1, LEU 1, ARG 1, HIS 1, PHE 1, SER 1 (residue and the binding sites it lines).

Found with

  • HFP · Alpha-hydroxyfarnesylphosphonic acid
  • ZN · Zinc ion

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