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Ligand · GST

GST · Geranyl S-thiolodiphosphate

GST, Geranyl S-thiolodiphosphate (C10 H20 O6 P2 S, 330.3 g/mol), in the MolNFT structures on GenesisL1: bound in 21 records (14 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
GST
Formula
C10 H20 O6 P2 S
Class
ligand
Structures
21
PDB entries
14

Binding sites

GST in 21 structures; the first of them:

  • 5KCQ · Crystal structure of the aromatic prenyltransferase AtaPT from Aspergillus terreus A8-4… · GST A501 · binds GLU91, ARG104, LYS188, TYR190, TYR268, ASN328, GLN342, TYR344 and 2 more
  • 5KD0 · Crystal structure of the aromatic prenyltransferase AtaPT(E91A) mutant from Aspergillus… · GST A502 · binds LYS95, ARG104, LYS188, TYR190, ARG264, LYS266, TYR268, PHE325 and 7 more
  • 5Z44 · Crystal structure of prenyltransferase AmbP1 complexed with GSPP · GST A401 · binds ARG46, ARG60, LYS117, TRP119, ASN168, TYR170, ARG223, TYR227 and 2 more
  • 5Z45 · Crystal structure of prenyltransferase AmbP1 pH6.5 complexed with GSPP and cis-indolyl… · GST A401 · binds ARG46, ARG60, HIS62, LYS117, TRP119, ASN168, TYR170, ARG223 and 3 more
  • 6VKZ · Crystal Structure of the N-prenyltransferase DabA in Complex with GSPP and Mg2+ · GST A503 · binds THR143, CYS147, TYR163, MET166, TYR167, ASN170, LYS177, ARG290 and 11 more
  • 6VL0 · Crystal Structure of the N-prenyltransferase DabA in Complex with GSPP and Mn2+ · GST A502 · binds THR143, CYS147, TYR163, MET166, TYR167, ASN170, LYS177, ARG306 and 9 more
  • 7VMY · Crystal structure of LimF prenyltransferase bound with GSPP · GST A402 · binds LYS58, ARG68, ASP126, LYS135, LYS137, PHE139, ASP176, GLU186 and 12 more
  • 8DAZ · Crystal structure of DMATS1 prenyltransferase in complex with L-Trp and GSPP · GST C501 · binds GLU90, TYR91, SER92, LYS94, ARG105, TYR106, ALA107, PHE174 and 12 more
  • 8ISA · CrtMLIKE with one GsPP molecule · GST A301 · binds PHE22, PHE26, ARG45, VAL129, ALA130, VAL133, GLY134, LEU137 and 11 more
  • 5KCQ · Crystal structure of the aromatic prenyltransferase atapt from aspergillus terreus A8-4… · GST A501 · binds GLU91, ARG104, LYS188, TYR190, TYR268, ASN328, GLN342, TYR344 and 2 more
  • 5KCY · Crystal structure of the aromatic prenyltransferase atapt from aspergillus terreus A8-4… · GST A502 · binds LYS95, ARG104, LYS188, TYR190, ARG264, LYS266, TYR268, LEU269 and 9 more
  • 5KD0 · Crystal structure of the aromatic prenyltransferase ATAPT(E91A) mutant from aspergillus… · GST A502 · binds LYS95, ARG104, LYS188, TYR190, ARG264, LYS266, TYR268, PHE325 and 7 more
  • 5XK9 · Crystal structure of isosesquilavandulyl diphosphate synthase from streptomyces sp.… · GST A501 · binds PRO8, ASP9, GLY10, MET11, ARG12, ARG13, TYR26, VAL52 and 8 more
  • 5Z44 · Crystal structure of prenyltransferase AMBP1 complexed with gspp · GST A401 · binds ARG46, ARG60, LYS117, TRP119, ASN168, TYR170, ARG223, TYR227 and 2 more
  • 5Z45 · Crystal structure of prenyltransferase AMBP1 PH6.5 complexed with gspp and cis-indolyl… · GST A401 · binds ARG46, ARG60, HIS62, LYS117, TRP119, ASN168, TYR170, ARG223 and 3 more
  • 5Z46 · Crystal structure of prenyltransferase AMBP1 PH8 complexed with gspp and cis-indolyl… · GST B401 · binds MET44, ARG46, ARG60, LYS117, TRP119, ASN168, TYR170, ARG223 and 4 more
  • 6IME · RV2361C complex with substrate analogues · GST A301 · binds MET75, ASP76, GLY77, ASN78, GLY79, ARG80, ARG89, HIS93 and 5 more
  • 6VKZ · Crystal structure of the N-prenyltransferase daba in complex with gspp and MG2+ · GST A503 · binds THR143, TYR163, MET166, TYR167, ASN170, LYS177, ARG306, THR310 and 8 more
  • 6VL0 · Crystal structure of the N-prenyltransferase daba in complex with gspp and MN2+ · GST A502 · binds THR143, CYS147, TYR163, MET166, TYR167, ASN170, ARG306, THR310 and 7 more
  • 7VMW · Crystal structure of limf prenyltransferase bound with a peptide substrate and gspp · GST A402 · binds LYS58, ARG68, LYS135, LYS137, PHE139, ARG141, HIS172, GLU186 and 8 more
  • 7VMY · Crystal structure of limf prenyltransferase bound with gspp · GST A402 · binds LYS58, ARG68, LYS135, LYS137, GLU186, TYR188, ALA233, VAL235 and 6 more

Residues it binds most

TYR 40, ARG 40, LYS 28, ASN 39, ALA 17, MET 19, VAL 14, GLY 18, PHE 19, TRP 19 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • 8XL · 3-[(Z)-2-isocyanoethenyl]-1H-indole
  • XBU · methyl (2~{R})-3-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-4-oxidanyl-5-oxidanylidene-furan-2-carboxylate
  • MN · Manganese (II) ion
  • BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol
  • ACE · Acetyl group
  • DMA · Dimethylallyl diphosphate
  • ISY · 3-methylbut-3-enylsulfanyl(phosphonooxy)phosphinic acid
  • PPV · Pyrophosphate
  • TRP · Tryptophan
  • CL · Chloride ion
  • CO3 · Carbonate ion

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