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Ligand · CSF

CSF · Cytidine-5'-monophosphate-3-fluoro-N-acetyl-neuraminic acid

CSF, Cytidine-5'-monophosphate-3-fluoro-N-acetyl-neuraminic acid (C20 H30 F N4 O16 P, 632.4 g/mol), in the MolNFT structures on GenesisL1: bound in 24 records (12 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
CSF
Formula
C20 H30 F N4 O16 P
Class
ligand
Structures
24
PDB entries
12

Binding sites

CSF in 24 structures; the first of them:

  • 1RO7 · Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex… · CSF C1001 · binds GLY8, ASN9, GLY10, PRO11, CYS30, ASN31, GLN32, ASN51 and 19 more
  • 2DRJ · Xray structure of alpha-2,3/8-sialyltransferase CstII F91Y mutant · CSF A1001 · binds GLY8, ASN9, GLY10, PRO11, CYS30, ASN31, GLN32, ASN51 and 11 more
  • 2IHJ · crystal structure of multifunctional sialyltransferase from pasteurella multocida with… · CSF A1741 · binds ALA35, SER36, LEU37, ARG63, ASP141, GLY142, SER143, MET144 and 17 more
  • 2IHK · crystal structure of multifunctional sialyltransferase from pasteurella multocida with… · CSF A1741 · binds ALA35, SER36, LEU37, LEU40, ARG63, ASP141, GLY142, SER143 and 18 more
  • 2IHZ · Crystal structure of multifunctional sialyltransferase from pasteurella multocida with… · CSF A1741 · binds ALA35, SER36, LEU37, LEU40, ARG63, ASP141, GLY142, SER143 and 19 more
  • 2IY7 · crystal structure of the sialyltransferase PM0188 with CMP-3FNeuAc · CSF A1414 · binds ALA35, SER36, LEU37, LEU40, ARG63, ASP141, GLY142, SER143 and 19 more
  • 2IY8 · Crystal structure of the sialyltransferase PM0188 with CMP-3FNeuAc and lactose · CSF A1415 · binds ALA35, SER36, LEU37, LEU40, ARG63, ASP141, GLY142, SER143 and 18 more
  • 2P2V · Crystal structure analysis of monofunctional alpha-2,3-sialyltransferase Cst-I from… · CSF A1001 · binds GLY23, ASN24, GLY25, PRO26, CYS45, ASN46, GLN47, ASN66 and 17 more
  • 2WQQ · Crystallographic analysis of monomeric CstII · CSF A1259 · binds GLY8, ASN9, GLY10, PRO11, CYS30, ASN31, GLN32, ASN51 and 14 more
  • 2YK7 · Structure of Neisseria LOS-specific sialyltransferase (NST), in complex with… · CSF A1371 · binds LEU254, GLY255, PRO257, ALA278, PRO279, HIS280, PRO281, ARG282 and 7 more
  • 4R84 · Crystal structure of Sialyltransferase from Photobacterium damsela with CMP-3F(a)Neu5Ac… · CSF A501 · binds SER122, ARG150, THR356, GLY357, THR358, THR359, LYS399, GLY400 and 12 more
  • 5BO9 · Structure of human sialyltransferase ST8SiaIII in complex with CMP-3FNeu5Ac and… · CSF A412 · binds GLY166, ASN167, SER168, GLY169, CYS189, ASN190, ASN211, SER213 and 16 more
  • 1RO7 · Structural analysis of the sialyltransferase cstii from campylobacter jejuni in complex… · CSF C1001 · binds GLY8, ASN9, GLY10, PRO11, CYS30, ASN31, GLN32, ASN51 and 19 more
  • 2DRJ · Xray structure of alpha-2,3/8-sialyltransferase cstii F91Y mutant · CSF A1001 · binds GLY8, ASN9, GLY10, PRO11, CYS30, ASN31, GLN32, ASN51 and 11 more
  • 2IHJ · Crystal structure of multifunctional sialyltransferase from pasteurella multocida with… · CSF A1741 · binds ALA35, SER36, LEU37, ARG63, ASP141, GLY142, SER143, MET144 and 17 more
  • 2IHK · Crystal structure of multifunctional sialyltransferase from pasteurella multocida with… · CSF A1741 · binds ALA35, SER36, LEU37, LEU40, ARG63, ASP141, GLY142, SER143 and 18 more
  • 2IHZ · Crystal structure of multifunctional sialyltransferase from pasteurella multocida with… · CSF A1741 · binds ALA35, SER36, LEU37, LEU40, ARG63, ASP141, GLY142, SER143 and 19 more
  • 2IY7 · Crystal structure of the sialyltransferase PM0188 with cmp-3FNEUAC · CSF A1414 · binds ALA35, SER36, LEU37, LEU40, ARG63, ASP141, GLY142, SER143 and 19 more
  • 2IY8 · Crystal structure of the sialyltransferase PM0188 with cmp-3FNEUAC and lactose · CSF A1415 · binds ALA35, SER36, LEU37, LEU40, ARG63, ASP141, GLY142, SER143 and 18 more
  • 2P2V · Crystal structure analysis of monofunctional alpha-2,3- sialyltransferase cst-I from… · CSF A1001 · binds GLY23, ASN24, GLY25, PRO26, CYS45, ASN46, GLN47, ASN66 and 17 more
  • 2WQQ · Crystallographic analysis of monomeric cstii · CSF A1259 · binds GLY8, ASN9, GLY10, PRO11, CYS30, ASN31, GLN32, ASN51 and 14 more
  • 2YK7 · Structure of neisseria los-specific sialyltransferase (nst), in complex with… · CSF A1371 · binds LEU254, GLY255, PRO257, ALA278, PRO279, HIS280, PRO281, ARG282 and 7 more
  • 4R84 · Crystal structure of sialyltransferase from photobacterium damsela with cmp-3F(A)NEU5AC… · CSF A501 · binds SER122, ARG150, THR356, GLY357, THR358, THR359, LYS399, GLY400 and 12 more
  • 5BO9 · Structure of human sialyltransferase ST8SIAIII in complex with cmp- 3FNEU5AC and… · CSF A412 · binds GLY166, ASN167, SER168, GLY169, CYS189, ASN190, ASN211, SER213 and 16 more

Residues it binds most

GLY 38, SER 38, THR 38, ASN 18, LEU 36, ILE 38, PHE 36, PRO 38, HIS 36, TYR 18 (residue and the binding sites it lines).

Found with

  • GAL · beta-D-galactopyranose
  • EDO · 1,2-ethanediol
  • NGS · 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranose
  • CA · Calcium ion
  • BGC · beta-D-glucopyranose
  • FUC · alpha-L-fucopyranose
  • GLC · alpha-D-glucopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • SIA · N-acetyl-alpha-neuraminic acid
  • CL · Chloride ion
  • 1PE · Pentaethylene glycol
  • IPA · Isopropyl alcohol

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