MolNFT v2 · #51030 · protein
Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP
2UV5 · 5'-AMP-activated protein kinase subunit gamma-1: “Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP”. X-ray diffraction at 1.69, 1 ligand (AMZ), 2 pockets (best druggability…
- PDB
- 2UV5
- Type
- protein
- Length
- 143 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.69
- Source
- HOMO SAPIENS
- Molecule
- 5'-AMP-activated protein kinase subunit gamma-1
- UniProt
- P54619
- Ligands
- AMZ
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · resolution 1.69 · 1 distinct chain · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5'-AMP-activated protein kinase subunit gamma-1 | protein | 143 | 37% helix, 23% strand | P54619 |
Ligands and binding sites
- AMZ · Aminoimidazole 4-carboxamide ribonucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.38 | 0.77 | 16 | AMZ |
| 2 | 69 | 0.36 | 0.77 | 15 | empty |
Compared structures
- 2UV5 · Crystal structure of a cbs domain pair from the regulatory GAMMA1 subunit of human ampk… · the same entry in another collection · chain A against A, TM-score 1.00
- P54619 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit gamma-1… · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54619
- Elsewhere: RCSB PDB 2UV5 · PDBe 2UV5 · UniProt P54619
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