MolNFT v2 · #27412 · protein

Crystal Structure of the N-terminal Domain of Nup159

1XIP · Nucleoporin NUP159: “Crystal Structure of the N-terminal Domain of Nup159”. X-ray diffraction at 2.5, 4 pockets (best druggability 0.64). MolNFT v2 #27412 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XIP
Type: protein
Length: 367 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.5
Source: Saccharomyces cerevisiae
Molecule: Nucleoporin NUP159
UniProt: P40477
Pockets: 4 · best druggability 0.64

Structure

x-ray diffraction · resolution 2.5 · 1 distinct chain · 4% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NUP159	protein	367	4% helix, 53% strand	P40477

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	373	0.64	0.79	36	empty
2	65	0.46	0.83	18	empty
3	111	0.45	0.78	18	empty
4	65	0.38	0.79	14	empty

Modifications

Observed in the structure: 3 modified (engineered).

Compared structures

1XIP · Crystal structure of the N-terminal domain of NUP159 · the same entry in another collection · chain A against A, TM-score 1.00
P40477 · AlphaFold monomer V2.0 prediction for nucleoporin NUP159 (P40477) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P40477
Elsewhere: RCSB PDB 1XIP · PDBe 1XIP · UniProt P40477

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.