MolNFT v2 · #226405 · protein
Cryo-EM structure of prolactin-releasing peptide recognition with Gq
8ZPT · Guanine nucleotide-binding protein G(324) subunit alpha-1,: “Cryo-EM structure of prolactin-releasing peptide recognition with Gq”. Electron microscopy at 2.96, 19 pockets (best druggability 0.82). MolNFT v2 #226405 on GenesisL1: 3D…
- PDB
- 8ZPT
- Type
- protein
- Length
- 1,162 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.96
- Source
- Homo sapiens
- Molecule
- Guanine nucleotide-binding protein G(324) subunit alpha-1,; Guanine nucleotide-binding…
- UniProt
- P62873, P59768, P81277, P49683
- Pockets
- 19 · best druggability 0.82
Structure
electron microscopy · resolution 2.96 · 6 distinct chains · 35% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(324) subunit alpha-1, | protein | 229 | 46% helix, 17% strand | — |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 336 | 7% helix, 46% strand | P62873 |
| E | scfv16 | protein | 232 | 4% helix, 47% strand | — |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 53 | 57% helix, 0% strand | P59768 |
| L | Prolactin-releasing peptide PrRP20 | protein | 20 | 30% helix, 0% strand | P81277 |
| R | Prolactin-releasing peptide receptor | protein | 292 | 78% helix, 2% strand | P49683 |
Pockets
19 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.82 | 0.88 | 56 | empty |
| 2 | 81 | 0.75 | 0.97 | 27 | empty |
| 3 | 750 | 0.73 | 0.79 | 72 | empty |
| 4 | 434 | 0.66 | 0.79 | 45 | empty |
| 5 | 164 | 0.59 | 0.82 | 26 | empty |
Interfaces
7 interfaces between chains.
- B–G · 1948 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 1444 Ų buried · 24 hydrogen bonds · protein-protein
- L–R · 980 Ų buried · 2 hydrogen bonds · protein-protein
- A–R · 954 Ų buried · 9 hydrogen bonds · protein-protein
- A–E · 493 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.94
- P81277 · AlphaFold monomer V2.0 prediction for prolactin-releasing peptide (P81277) · a predicted model of the same protein · chain L against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P81277
- Every structure of UniProt P49683
- Elsewhere: RCSB PDB 8ZPT · PDBe 8ZPT · UniProt P62873 · UniProt P59768 · UniProt P81277 · UniProt P49683
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