MolNFT v2 · #224557 · protein
Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex
8WZ2 · G-alpha q: “Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex”. Electron microscopy at 2.73, 14 pockets (best druggability 0.82). MolNFT v2 #224557 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8WZ2
- Type
- protein
- Length
- 1,201 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.73
- Source
- Bos taurus; Homo sapiens; Rattus norvegicus
- Molecule
- G-alpha q; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; scFV16…
- UniProt
- P54311, P63212, Q8CE23, Q96P65
- Pockets
- 14 · best druggability 0.82
Structure
electron microscopy · resolution 2.73 · 6 distinct chains · 36% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G-alpha q | protein | 232 | 45% helix, 18% strand | — |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 8% helix, 46% strand | P54311 |
| E | scFV16 | protein | 230 | 3% helix, 47% strand | — |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 54 | 63% helix, 0% strand | P63212 |
| L | Orexigenic neuropeptide QRFP | protein | 25 | 48% helix, 0% strand | Q8CE23 |
| R | Pyroglutamylated RF-amide peptide receptor | protein | 322 | 78% helix, 5% strand | Q96P65 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 758 | 0.82 | 0.86 | 71 | empty |
| 2 | 848 | 0.75 | 0.79 | 88 | empty |
| 3 | 461 | 0.70 | 0.81 | 36 | empty |
| 4 | 161 | 0.63 | 0.85 | 34 | empty |
| 5 | 58 | 0.53 | 0.88 | 15 | empty |
Interfaces
7 interfaces between chains.
- B–G · 1971 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1376 Ų buried · 17 hydrogen bonds · protein-protein
- A–R · 1330 Ų buried · 10 hydrogen bonds · protein-protein
- L–R · 1045 Ų buried · 10 hydrogen bonds · protein-protein
- A–E · 615 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54311
- Every structure of UniProt P63212
- Every structure of UniProt Q8CE23
- Every structure of UniProt Q96P65
- Elsewhere: RCSB PDB 8WZ2 · PDBe 8WZ2 · UniProt P54311 · UniProt P63212 · UniProt Q8CE23 · UniProt Q96P65
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