MolNFT v2 · #223633 · protein
HTT in complex with HAP40 in the apo state.
8W15 · Huntingtin: “HTT in complex with HAP40 in the apo state.”. Electron microscopy at 2.72, 20 pockets (best druggability 0.83). MolNFT v2 #223633 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8W15
- Type
- protein
- Length
- 2,710 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.72
- Source
- Homo sapiens
- Molecule
- Huntingtin; 40-kDa huntingtin-associated protein
- UniProt
- P42858, P23610
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · resolution 2.72 · 2 distinct chains · 67% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Huntingtin | protein | 2431 | 66% helix, 1% strand | P42858 |
| B | 40-kDa huntingtin-associated protein | protein | 279 | 76% helix, 0% strand | P23610 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1051 | 0.83 | 0.84 | 96 | empty |
| 2 | 303 | 0.81 | 0.92 | 47 | empty |
| 3 | 230 | 0.80 | 0.93 | 42 | empty |
| 4 | 221 | 0.80 | 0.93 | 60 | empty |
| 5 | 169 | 0.79 | 0.95 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 5324 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- P23610 · AlphaFold monomer V2.0 prediction for 40-kda huntingtin-associated protein (P23610) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42858
- Every structure of UniProt P23610
- Elsewhere: RCSB PDB 8W15 · PDBe 8W15 · UniProt P42858 · UniProt P23610
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