MolNFT v2 · #22239 · protein
Crystal structure of the human MBL-associated protein 19 (MAp19)
1SZB · mannose binding lectin-associated serine protease-2 related…: “Crystal structure of the human MBL-associated protein 19 (MAp19)”. X-ray diffraction at 2.5, 1 ligand (CA), 2 pockets (best druggability 0.48). MolNFT v2 #22239 on…
- PDB
- 1SZB
- Type
- protein
- Length
- 333 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.5
- Source
- Homo sapiens
- Molecule
- mannose binding lectin-associated serine protease-2 related protein, MAp19 (19kDa)
- UniProt
- O00187
- Ligands
- CA
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · resolution 2.5 · 2 distinct chains · 0% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | mannose binding lectin-associated serine protease-2 related protein, MAp19 (19kDa) | protein | 167 | 0% helix, 41% strand | O00187 |
| B | mannose binding lectin-associated serine protease-2 related protein, MAp19 (19kDa) | protein | 166 | 0% helix, 42% strand | O00187 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 227 | 0.48 | 0.74 | 35 | empty |
| 2 | 74 | 0.29 | 0.72 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1278 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1SZB · Crystal structure of the human mbl-associated protein 19 (MAP19) · the same entry in another collection · chain A against A, TM-score 1.00
- O00187 · AlphaFold monomer V2.0 prediction for mannan-binding lectin serine protease 2 (O00187) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00187
- Elsewhere: RCSB PDB 1SZB · PDBe 1SZB · UniProt O00187
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