UniProt O00187
Mannan-binding lectin serine protease 2 A chain (O00187)
Mannan-binding lectin serine protease 2 A chain (UniProt O00187): 11 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00187
- Protein
- Mannan-binding lectin serine protease 2 A chain
- Experimental structures
- 11
- Predicted models
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
12 records of O00187 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Q3X | Crystal structure of the catalytic region of human MASP-2 | x-ray diffraction | A, B | — | — |
| 1Q3X | Crystal structure of the catalytic region of human masp-2 | x-ray diffraction | A, B | — | — |
| 1SZB | Crystal structure of the human MBL-associated protein 19 (MAp19) | x-ray diffraction | A, B | — | — |
| 1SZB | Crystal structure of the human mbl-associated protein 19 (MAP19) | x-ray diffraction | A, B | — | — |
| 1ZJK | Crystal structure of the zymogen catalytic region of human MASP-2 | x-ray diffraction | A | — | — |
| 1ZJK | Crystal structure of the zymogen catalytic region of human masp-2 | x-ray diffraction | A | — | — |
| 3TVJ | Catalytic fragment of MASP-2 in complex with its specific inhibitor developed by directed evolution… | x-ray diffraction | A, B | — | — |
| 3TVJ | Catalytic fragment of masp-2 in complex with its specific inhibitor developed by directed evolution… | x-ray diffraction | A, B | — | — |
| 4FXG | Complement C4 in complex with masp-2 | x-ray diffraction | G, H, I, J | — | — |
| 5JPM | Structure of the complex of human complement C4 with masp-2 rebuilt using imdff | x-ray diffraction | G, H, I, J | — | — |
| 7PQN | Catalytic fragment of MASP-2 in complex with ecotin | x-ray diffraction | A, B, aa, bb | — | 7 (best 0.75) |
| O00187 | AlphaFold monomer V2.0 prediction for mannan-binding lectin serine protease 2 (O00187) | predicted | A | — | — |
Experiment against prediction
- 4FXG chain H against the predicted model O00187: TM-score 0.97, RMSD 1.10 Å
- 7PQN chain B against the predicted model O00187: TM-score 0.97, RMSD 1.34 Å
- 7PQN chain bb against the predicted model O00187: TM-score 0.97, RMSD 1.16 Å
- 3TVJ chain B against the predicted model O00187: TM-score 0.97, RMSD 1.30 Å
- 3TVJ chain B against the predicted model O00187: TM-score 0.97, RMSD 1.30 Å
- 5JPM chain H against the predicted model O00187: TM-score 0.97, RMSD 1.25 Å
- 1Q3X chain B against the predicted model O00187: TM-score 0.96, RMSD 1.42 Å
- 1Q3X chain B against the predicted model O00187: TM-score 0.96, RMSD 1.42 Å
- 1Q3X chain A against the predicted model O00187: TM-score 0.96, RMSD 1.45 Å
- 1Q3X chain A against the predicted model O00187: TM-score 0.96, RMSD 1.45 Å
Elsewhere
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