MolNFT v2 · #222304 · protein

Crystal structure of Lsd18 (a flavin-dependent monooxygenase)

8UP4 · Flavin-dependent monooxygenase Lsd18: “Crystal structure of Lsd18 (a flavin-dependent monooxygenase)”. X-ray diffraction at 1.51, 2 ligands (FAD, CL), 8 pockets (best druggability 0.87). MolNFT v2 #222304 on GenesisL1: 3D structure…

PDB: 8UP4
Type: protein
Length: 936 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.51
Source: Streptomyces lasalocidi
Molecule: Flavin-dependent monooxygenase Lsd18
UniProt: B5M9L6
Ligands: FAD, CL
Pockets: 8 · best druggability 0.87

Structure

x-ray diffraction · resolution 1.51 · 1 distinct chain · 37% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Flavin-dependent monooxygenase Lsd18	protein	468	37% helix, 24% strand	B5M9L6

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1033	0.87	0.88	117	FAD, CL
2	502	0.84	0.90	45	empty
3	411	0.78	0.87	56	FAD, CL
4	167	0.52	0.79	28	empty
5	144	0.51	0.80	23	empty

Interfaces

1 interface between chains.

A–B · 469 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (nonstandard).

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B5M9L6
Elsewhere: RCSB PDB 8UP4 · PDBe 8UP4 · UniProt B5M9L6

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