MolNFT v2 · #216048 · protein

Structure of the human Guanine Nucleotide-Binding Protein G(K) Subunit Alpha

8OY1 · Guanine nucleotide-binding protein G(i) subunit alpha-3: “Structure of the human Guanine Nucleotide-Binding Protein G(K) Subunit Alpha”. X-ray diffraction at 3.34, 1 ligand (GDP), 2 pockets (best druggability 0.77). MolNFT v2…

PDB: 8OY1
Type: protein
Length: 315 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.34
Source: Homo sapiens
Molecule: Guanine nucleotide-binding protein G(i) subunit alpha-3
UniProt: P08754
Ligands: GDP
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · resolution 3.34 · 1 distinct chain · 50% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanine nucleotide-binding protein G(i) subunit alpha-3	protein	315	50% helix, 12% strand	P08754

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	802	0.77	0.81	77	GDP
2	93	0.33	0.73	15	empty

Compared structures

P08754 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08754
Elsewhere: RCSB PDB 8OY1 · PDBe 8OY1 · UniProt P08754

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.