MolNFT v2 · #215287 · protein
Structure of African swine fever virus topoisomerase II in complex with dsDNA
8KGS · DNA topoisomerase 2: “Structure of African swine fever virus topoisomerase II in complex with dsDNA”. X-ray diffraction at 2.603, 2 ligands (ANP, MG), 4 pockets (best druggability 0.74). MolNFT v2 #215287 on GenesisL1: 3D structure…
- PDB
- 8KGS
- Type
- protein
- Length
- 403 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.603
- Source
- African swine fever virus
- Molecule
- DNA topoisomerase 2
- UniProt
- A0A2X0THW2
- Ligands
- ANP, MG
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · resolution 2.603 · 1 distinct chain · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 2 | protein | 403 | 33% helix, 26% strand | A0A2X0THW2 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 318 | 0.74 | 0.86 | 43 | MG, ANP |
| 2 | 327 | 0.67 | 0.81 | 37 | empty |
| 3 | 145 | 0.43 | 0.75 | 27 | empty |
| 4 | 92 | 0.40 | 0.76 | 16 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2X0THW2
- Elsewhere: RCSB PDB 8KGS · PDBe 8KGS · UniProt A0A2X0THW2
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