Research workbench
Structure of African swine fever virus topoisomerase II in complex with dsDNA
Analyse Structure of African swine fever virus topoisomerase II in complex with dsDNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8KGS
- Type
- protein
- Length
- 403 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.603
- Source
- African swine fever virus
- Molecule
- DNA topoisomerase 2
- UniProt
- A0A2X0THW2
- Ligands
- ANP, MG
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · resolution 2.603 · 1 distinct chain · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 2 | protein | 403 | 33% helix, 26% strand | A0A2X0THW2 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 318 | 0.74 | 0.86 | 43 | MG, ANP |
| 2 | 327 | 0.67 | 0.81 | 37 | empty |
| 3 | 145 | 0.43 | 0.75 | 27 | empty |
| 4 | 92 | 0.40 | 0.76 | 16 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2X0THW2
- Elsewhere: RCSB PDB 8KGS · PDBe 8KGS · UniProt A0A2X0THW2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.