MolNFT v2 · #210357 · protein
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108
8G18: “Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108”. X-ray diffraction at 2.85, 5 ligands (YGW, NAG, MAN). MolNFT v2 #210357 on GenesisL1: 3D structure, binding sites and…
- PDB
- 8G18
- Type
- protein
- Length
- 1,443 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.85
- Source
- Rattus norvegicus; Xenopus laevis
- UniProt
- A0A1L8F5J9, Q00960
- Ligands
- YGW, NAG, MAN, BMA, NA
Structure
x-ray diffraction · resolution 2.85 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 359 | — | A0A1L8F5J9 |
| B, D | — | protein | 363 | — | Q00960 |
| C | — | protein | 358 | — | A0A1L8F5J9 |
Ligands and binding sites
- YGW · N-(4-{3-[4-(3,4-difluorophenyl)piperazin-1-yl]-2-oxopropoxy}phenyl)methanesulfonamide · ligand · 2 copies · chains A, B, C, D
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains A, B, C, D
- MAN · alpha-D-mannopyranose · sugar · 2 copies
- BMA · beta-D-mannopyranose · sugar
- NA · Sodium ion · metal · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1L8F5J9
- Every structure of UniProt Q00960
- Elsewhere: RCSB PDB 8G18 · PDBe 8G18 · UniProt A0A1L8F5J9 · UniProt Q00960
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