UniProt Q00960
Glutamate receptor ionotropic, NMDA 2B (Q00960)
Glutamate receptor ionotropic, NMDA 2B (UniProt Q00960): 60 experimental structures on GenesisL1, 14 ligands bound, 104 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q00960
- Protein
- Glutamate receptor ionotropic, NMDA 2B
- Experimental structures
- 60
- Predicted models
- 0
- Ligands
- 14
- Pockets
- 104 · 7 records with a druggable one
Structures
60 records of Q00960 in the MolNFT archive: 60 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JPW | Crystal structure of amino terminal domain of the NMDA receptor subunit NR2B | x-ray diffraction | A | — | — |
| 3JPW | Crystal structure of amino terminal domain of the NMDA receptor subunit NR2B | x-ray diffraction | A | — | — |
| 3JPY | Crystal structure of the zinc-bound amino terminal domain of the NMDA receptor subunit NR2B | x-ray diffraction | A | — | — |
| 3JPY | Crystal structure of the zinc-bound amino terminal domain of the NMDA receptor subunit NR2B | x-ray diffraction | A | — | — |
| 3QEL | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in… | x-ray diffraction | B, D | — | — |
| 3QEL | Crystal structure of amino terminal domains of the NMDA receptor subunit GLUN1 and GLUN2B in… | x-ray diffraction | B, D | — | — |
| 3QEM | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in… | x-ray diffraction | B, D | — | — |
| 3QEM | Crystal structure of amino terminal domains of the NMDA receptor subunit GLUN1 and GLUN2B in… | x-ray diffraction | B, D | — | — |
| 4PE5 | Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel | x-ray diffraction | B, D | — | — |
| 4PE5 | Crystal structure of GLUN1A/GLUN2B NMDA receptor ion channel | x-ray diffraction | B, D | — | — |
| 5B3J | Activation of NMDA receptors and the mechanism of inhibition by ifenprodil | x-ray diffraction | C, D | — | — |
| 5B3J | Activation of NMDA receptors and the mechanism of inhibition by ifenprodil | x-ray diffraction | C, D | — | — |
| 5FXG | GLUN1B-GLUN2B NMDA receptor in active conformation | electron microscopy | B, D | — | — |
| 5FXG | GLUN1B-GLUN2B NMDA receptor in active conformation | electron microscopy | B, D | — | — |
| 5FXH | GluN1b-GluN2B NMDA receptor in non-active-1 conformation | electron microscopy | B, D | — | — |
| 5FXH | GLUN1B-GLUN2B NMDA receptor in non-active-1 conformation | electron microscopy | B, D | — | — |
| 5FXI | GluN1b-GluN2B NMDA receptor structure in non-active-2 conformation | electron microscopy | B, D | — | — |
| 5FXI | GLUN1B-GLUN2B NMDA receptor structure in non-active-2 conformation | electron microscopy | B, D | — | — |
| 5FXJ | GLUN1B-GLUN2B NMDA receptor structure-class X | electron microscopy | B, D | — | — |
| 5FXK | GluN1b-GluN2B NMDA receptor structure-Class Y | electron microscopy | B, D | — | — |
| 5FXK | GLUN1B-GLUN2B NMDA receptor structure-class Y | electron microscopy | B, D | — | — |
| 5TPZ | Crystal structure of amino terminal domains of the NMDA receptor subunit GLUN1 and GLUN2B in apo… | x-ray diffraction | D | NAG | — |
| 6CNA | GLUN1-GLUN2B NMDA receptors with exon 5 | electron microscopy | B, D | NAG | — |
| 6E7R | Heterodimer of the GLUN1B-GLUN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor… | x-ray diffraction | B, D | CL, NAG, HYS | — |
| 6E7S | Heterodimer of the GLUN1B-GLUN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor… | x-ray diffraction | B, D | CL, NAG, HZ4 | — |
| 6E7T | Heterodimer of the GLUN1B-GLUN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor… | x-ray diffraction | B, D | CL, NAG, HYY | — |
| 6E7U | Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor… | x-ray diffraction | B, D | CL, NAG, HX7 | 13 (best 0.77) |
| 6E7U | Heterodimer of the GLUN1B-GLUN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor… | x-ray diffraction | B, D | CL, NAG, HX7 | — |
| 6E7V | Heterodimer of the GLUN1B-GLUN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor… | x-ray diffraction | B, D | CL, NAG, T88 | — |
| 6E7W | Heterodimer of the GLUN1B-GLUN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor… | x-ray diffraction | B, D | CL, NAG, HXM | — |
| 6E7X | Heterodimer of the GLUN1B-GLUN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor… | x-ray diffraction | B, D | CL, NAG, T97 | — |
| 6WHR | GLUN1B-GLUN2B NMDA receptor in non-active 2 conformation at 4 ångström resolution | electron microscopy | B, D | NAG | — |
| 6WHS | GLUN1B-GLUN2B NMDA receptor in non-active 1 conformation at 3.95 ångström resolution | electron microscopy | B, D | NAG | — |
| 6WHT | GLUN1B-GLUN2B NMDA receptor in active conformation at 4.4 ångström resolution | electron microscopy | B, D | NAG | — |
| 6WHU | GLUN1B-GLUN2B NMDA receptor in complex with sdz 220-040 and L689,560, class 1 | electron microscopy | B, D | NAG | — |
| 6WHV | GluN1b-GluN2B NMDA receptor in complex with SDZ 220-040 and L689,560, class 2 | electron microscopy | B, D | NAG | — |
| 6WHV | GLUN1B-GLUN2B NMDA receptor in complex with sdz 220-040 and L689,560, class 2 | electron microscopy | B, D | NAG | — |
| 6WI0 | GLUN1B-GLUN2B NMDA receptor in complex with GLUN1 antagonist L689,560, class 2 | electron microscopy | B, D | NAG | — |
| 7SAA | Glycine and glutamate bound GLUN1A-GLUN2B NMDA receptors in non-active 1 conformation at 2.97… | electron microscopy | B, D | NAG | — |
| 7SAB | Phencyclidine-bound GluN1a-GluN2B NMDA receptors | electron microscopy | B, D | NAG, 1PC | — |
| 7SAB | Phencyclidine-bound GLUN1A-GLUN2B NMDA receptors | electron microscopy | B, D | NAG, 1PC | — |
| 7SAC | S-(+)-ketamine bound GluN1a-GluN2B NMDA receptors at 3.69 Angstrom resolution | electron microscopy | B, D | NAG, GLU, JC9 | 15 (best 0.84) |
| 7SAC | S-(+)-ketamine bound GLUN1A-GLUN2B NMDA receptors at 3.69 ångström resolution | electron microscopy | B, D | NAG, JC9 | — |
| 7SAD | Memantine-bound GluN1a-GluN2B NMDA receptors | electron microscopy | B, D | NAG, 377 | — |
| 7SAD | Memantine-bound GLUN1A-GLUN2B NMDA receptors | electron microscopy | B, D | NAG, 377 | — |
| 7TE6 | Crystal structure of GLUN1B-2B atd complexed to FAB5 anti-GLUN2B antibody | x-ray diffraction | B, F | — | — |
| 7TE9 | Cryo-EM structure of GLUN1B-2B nmdar complexed to FAB2 CLASS1 | electron microscopy | B, D | — | — |
| 7TEB | Cryo-EM structure of GLUN1B-2B nmdar complexed to FAB2 non-ACTIVE1- like | electron microscopy | B, D | — | — |
| 7TEE | Cryo-EM structure of GLUN1B-2B nmdar complexed to FAB2 non-ACTIVE2- like | electron microscopy | B, D | — | — |
| 7TEQ | Cryo-EM structure of GLUN1B-2B nmdar in complex with FAB5 active conformation | electron microscopy | B, D | — | — |
| 7TER | Cryo-EM structure of GLUN1B-2B nmdar in complex with FAB5 non-ACTIVE2 conformation | electron microscopy | B, D | — | — |
| 7TES | Cryo-EM structure of GLUN1B-2B nmdar in complex with FAB5 in non- ACTIVE1 conformation | electron microscopy | B, D | — | — |
| 7TET | Cryo-EM structure of GLUN1B-2B nmdar in complex with FAB5 in non- ACTIVE2-like conformation | electron microscopy | B, D | — | — |
| 8G18 | Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor… | x-ray diffraction | B, D | NAG, YGW | — |
| 8VUY | Rat GluN1-2B with Fab 003-102 | electron microscopy | B, D | — | 15 (best 0.86) |
| 9ARF | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in… | electron microscopy | B, D | NAG, GLU | 18 (best 0.82) |
| 9ARG | Rat GluN1-GluN2B NMDA receptor channel in apo conformation | electron microscopy | B, D | — | 13 (best 0.84) |
| 9ARH | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine | electron microscopy | B, D | NAG | 16 (best 0.84) |
| 9ARI | Rat GluN1-GluN2B NMDA receptor channel in complex with glutamate | electron microscopy | B, D | GLU | 14 (best 0.84) |
| Q00960 | AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2B (Q00960) | — | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 27 records
- CL · Chloride ion · in 8 records
- GLU · Glutamic acid · in 3 records
- 1PC · 1-(phenyl-1-cyclohexyl)piperidine · in 2 records
- 377 · Memantine · in 2 records
- HX7 · N-{4-[(2S)-3-{butyl[2-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropoxy]phenyl}methanesulfonamide · in 2 records
- JC9 · (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one · in 2 records
- HXM · N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](propan-2-yl)amino}-2-hydroxypropoxy]phenyl}methanesulfonamide · in 1 record
- HYS · N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropoxy]phenyl}methanesulfonamide · in 1 record
- HYY · N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](propyl) amino}-2-hydroxypropoxy]phenyl}methanesulfonamide · in 1 record
- HZ4 · N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](ethyl) amino}-2-hydroxypropoxy]phenyl}methanesulfonamide · in 1 record
- T88 · N-{4-[(2R)-3-{butyl[2-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropoxy]phenyl}methanesulfonamide · in 1 record
- T97 · N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](2-methylpropyl)amino}-2-hydroxypropoxy]phenyl}methanesulfonamide · in 1 record
- YGW · N-(4-{3-[4-(3,4-difluorophenyl)piperazin-1-yl]-2-oxopropoxy}phenyl)methanesulfonamide · in 1 record
Elsewhere
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