MolNFT v2 · #196426 · protein
Human meprin alpha inhibitory complex with compound 10d (N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-beta-alaninamide)
7UAF: “Human meprin alpha inhibitory complex with compound 10d (N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydr…”. Electron microscopy at 2.4, 6 ligands (M6X, NAG, BMA). MolNFT v2 #196426 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7UAF
- Type
- protein
- Length
- 2,131 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.4
- Source
- Homo sapiens
- UniProt
- Q16819
- Ligands
- M6X, NAG, BMA, FUC, CA, ZN
Structure
electron microscopy · resolution 2.4 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | — | protein | 535 | — | Q16819 |
| C | — | protein | 532 | — | Q16819 |
| D | — | protein | 529 | — | Q16819 |
Ligands and binding sites
- M6X · N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-beta-alaninamide · ligand · 4 copies · chains B, A, C, D
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 34 copies · chains B, A, C, D
- BMA · beta-D-mannopyranose · sugar · 4 copies
- FUC · alpha-L-fucopyranose · sugar · 4 copies · chains B, A, C, D
- CA · Calcium ion · metal · 8 copies · chains B, A, C, D
- ZN · Zinc ion · metal · 4 copies · chains B, A, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- Q16819 · AlphaFold monomer V2.0 prediction for meprin a subunit alpha (Q16819) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16819
- Elsewhere: RCSB PDB 7UAF · PDBe 7UAF · UniProt Q16819
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