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UniProt Q16819

Meprin A subunit alpha (Q16819)

Meprin A subunit alpha (UniProt Q16819), EC 3.4.24.18: 4 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt
Q16819
Protein
Meprin A subunit alpha
EC
3.4.24.18
Experimental structures
4
Predicted models
1
Ligands
6
Pockets
28 · 3 records with a druggable one

Structures

5 records of Q16819 in the MolNFT archive: 4 experimental, 1 predicted.

EntryTitleMethodChainsLigandsPockets
7UACHuman pro-meprin alpha (zymogen state)electron microscopyHNAG, FUC, CA, ZN5 (best 0.75)
7UAEHuman meprin alpha (active state)electron microscopyANAG, BMA, FUC, CA, ZN5 (best 0.79)
7UAFHuman meprin alpha inhibitory complex with compound 10d…electron microscopyB, A, C, DNAG, FUC, M6X, CA, ZN—
7UAIMeprin alpha helix in complex with fetuin-Belectron microscopyE, B, C, DNAG, BMA, FUC, CA, ZN18 (best 0.82)
Q16819AlphaFold monomer V2.0 prediction for meprin a subunit alpha (Q16819)predictedA——

Ligands

  • CA · Calcium ion · in 4 records
  • FUC · alpha-L-fucopyranose · in 4 records
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
  • ZN · Zinc ion · in 4 records
  • BMA · beta-D-mannopyranose · in 2 records
  • M6X · N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-beta-alaninamide · in 1 record

Experiment against prediction

Elsewhere

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