MolNFT v2 · #194701 · protein
The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Lumacaftor (VX-809)
7SVD: “The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg…”. Electron microscopy at 2.7, 7 ligands (CLR, ATP, D10). MolNFT v2 #194701 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7SVD
- Type
- protein
- Length
- 1,190 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.7
- Source
- Homo sapiens
- UniProt
- P13569
- Ligands
- CLR, ATP, D10, D12, VX8, MG, UNX
Structure
electron microscopy · resolution 2.7 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1173 | — | P13569 |
| B | — | protein | 17 | — | — |
Ligands and binding sites
- CLR · Cholesterol · ligand · 3 copies · chains A
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A
- D10 · Decane · ligand · 2 copies · chains A
- D12 · Dodecane · ligand
- VX8 · Lumacaftor · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
- UNX · Unknown atom or ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7SVD · The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator… · the same entry in another collection · chain A against A, TM-score 1.00
- P13569 · AlphaFold monomer V2.0 prediction for cystic fibrosis transmembrane conductance regulator… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13569
- Elsewhere: RCSB PDB 7SVD · PDBe 7SVD · UniProt P13569
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