MolNFT v2 · #194003 · protein

Memantine-bound GluN1a-GluN2B NMDA receptors

7SAD: “Memantine-bound GluN1a-GluN2B NMDA receptors”. Electron microscopy at 3.96, 2 ligands (377, NAG). MolNFT v2 #194003 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7SAD
Type: protein
Length: 3,160 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.96
Source: Rattus norvegicus
UniProt: P35439, Q00960
Ligands: 377, NAG

Structure

electron microscopy · resolution 3.96 · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	—	protein	795	—	P35439
B, D	—	protein	785	—	Q00960

Ligands and binding sites

377 · Memantine · ligand · chains B, C, D
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 15 copies · chains B, C, D, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7SAD · Memantine-bound GLUN1A-GLUN2B NMDA receptors · the same entry in another collection · chain A against A, TM-score 1.00
P35439 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 1 (P35439) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35439
Every structure of UniProt Q00960
Elsewhere: RCSB PDB 7SAD · PDBe 7SAD · UniProt P35439 · UniProt Q00960

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