Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme with Coenzyme A bound at the hydratase, thiolase active sites and additional binding site (CoA(ECH2))

Structure

x-ray diffraction · resolution 2.79 · 3 distinct chains.

Ligands and binding sites

• COA · Coenzyme A · ligand · 6 copies · chains A, B, C, D
• PAP · 3'-phosphate-adenosine-5'-diphosphate · ligand · chains B, C
• ADP · Adenosine-5'-diphosphate · ligand · chains A, D
• SO4 · Sulfate ion · ion · 26 copies · chains A, C, D, B
• GOL · Glycerol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7O4S · Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme with coenzyme… · the same entry in another collection · chain A against A, TM-score 1.00
• O53871 · AlphaFold monomer V2.0 prediction for putative acyltransferase RV0859 (O53871) · a predicted model of the same protein · chain C against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O53872
• Every structure of UniProt O53871
• Elsewhere: RCSB PDB 7O4S · PDBe 7O4S · UniProt O53872 · UniProt O53871