MolNFT v2 · #187506 · protein

Cryo-EM structure of minimal TRPV1 with 2 bound RTX in adjacent pockets

7MZA: “Cryo-EM structure of minimal TRPV1 with 2 bound RTX in adjacent pockets”. Electron microscopy at 3.46, 3 ligands (XJ7, 6EU, NA). MolNFT v2 #187506 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7MZA
Type: protein
Length: 2,229 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.46
Source: Rattus norvegicus
UniProt: O35433
Ligands: XJ7, 6EU, NA

Structure

electron microscopy · resolution 3.46 · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	577	—	O35433
D, C	—	protein	537	—	O35433
B	—	protein	578	—	O35433

Ligands and binding sites

XJ7 · (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2r,3s,4s,5r, 6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate · ligand · 2 copies · chains A, D, B
6EU · resiniferatoxin · ligand · 2 copies · chains D, C, B
NA · Sodium ion · metal · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7MZA · Cryo-EM structure of minimal TRPV1 with 2 bound rtx in adjacent pockets · the same entry in another collection · chain A against A, TM-score 1.00
O35433 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O35433
Elsewhere: RCSB PDB 7MZA · PDBe 7MZA · UniProt O35433

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