MolNFT v2 · #187137 · protein
Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab
7MN8: “Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab”. Electron microscopy at 3.45, 3 ligands (NAG, BMA, MAN). MolNFT v2 #187137 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MN8
- Type
- protein
- Length
- 1,661 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.45
- Source
- Escherichia coli; Homo sapiens
- UniProt
- P21860, P04626, P0AEX9
- Ligands
- NAG, BMA, MAN
Structure
electron microscopy · resolution 3.45 · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 599 | — | P21860 |
| H | — | protein | 49 | — | — |
| B | — | protein | 579 | — | P04626, P0AEX9 |
| C | — | protein | 214 | — | — |
| D | — | protein | 220 | — | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 11 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar
- MAN · alpha-D-mannopyranose · sugar · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7MN8 · Structure of the HER2/HER3/NRG1B heterodimer extracellular domain bound to trastuzumab Fab · the same entry in another collection · chain B against B, TM-score 1.00
- P04626 · AlphaFold monomer V2.0 prediction for receptor tyrosine-protein kinase erbb-2 (P04626) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P21860 · AlphaFold monomer V2.0 prediction for receptor tyrosine-protein kinase erbb-3 (P21860) · a predicted model of the same protein · chain A against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21860
- Every structure of UniProt P04626
- Every structure of UniProt P0AEX9
- Elsewhere: RCSB PDB 7MN8 · PDBe 7MN8 · UniProt P21860 · UniProt P04626 · UniProt P0AEX9
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