UniProt P21860
Isoform 4 of Receptor tyrosine-protein kinase erbB-3 (P21860)
Isoform 4 of Receptor tyrosine-protein kinase erbB-3 (UniProt P21860), EC 2.7.10.1: 36 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 7 pockets. Binding sites, druggability and experiment against…
- UniProt
- P21860
- Protein
- Isoform 4 of Receptor tyrosine-protein kinase erbB-3
- EC
- 2.7.10.1
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 7 · 2 records with a druggable one
Structures
37 records of P21860 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1M6B | Structure of the HER3 (ERBB3) Extracellular Domain | x-ray diffraction | A, B | — | — |
| 1M6B | Structure of the HER3 (ERBB3) extracellular domain | x-ray diffraction | A, B | — | — |
| 2L9U | Spatial structure of dimeric ErbB3 transmembrane domain | solution nmr | A, B | — | — |
| 2L9U | Spatial structure of dimeric ERBB3 transmembrane domain | solution nmr | A, B | — | — |
| 3KEX | Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor… | x-ray diffraction | A, B | — | — |
| 3KEX | Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor… | x-ray diffraction | A, B | — | — |
| 3LMG | Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP | x-ray diffraction | A, B | — | — |
| 3LMG | Crystal structure of the ERBB3 kinase domain in complex with AMP-pnp | x-ray diffraction | A, B | — | — |
| 3P11 | anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region | x-ray diffraction | A | — | — |
| 3P11 | Anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region | x-ray diffraction | A | — | — |
| 4LEO | Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3… | x-ray diffraction | C | — | — |
| 4LEO | Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human HER3… | x-ray diffraction | C | — | — |
| 4P59 | HER3 extracellular domain in complex with Fab fragment of MOR09825 | x-ray diffraction | A | — | — |
| 4P59 | HER3 extracellular domain in complex with Fab fragment of MOR09825 | x-ray diffraction | A | — | — |
| 4RIW | Crystal structure of an EGFR/HER3 kinase domain heterodimer | x-ray diffraction | A, C | — | — |
| 4RIW | Crystal structure of an EGFR/HER3 kinase domain heterodimer | x-ray diffraction | A, C | — | — |
| 4RIX | Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated… | x-ray diffraction | A, C | — | — |
| 4RIX | Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated… | x-ray diffraction | A, C | — | — |
| 4RIY | Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated… | x-ray diffraction | A, C | — | — |
| 4RIY | Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated… | x-ray diffraction | A, C | — | — |
| 5CUS | Crystal structure of SERBB3-FAB3379 complex | x-ray diffraction | A, B, C, D | — | — |
| 5O4O | HER3 in complex with Fab MF3178 | x-ray diffraction | C | NAG | 3 (best 0.52) |
| 5O4O | HER3 in complex with Fab MF3178 | x-ray diffraction | C | NAG | — |
| 5O7P | HER3 in complex with Fab MF3178 | x-ray diffraction | C | NAG, BMA | — |
| 5O7P | HER3 in complex with Fab MF3178 | x-ray diffraction | C | NAG, BMA | — |
| 6KBI | Crystal structure of ErbB3 N418Q mutant | x-ray diffraction | A, B | NAG | — |
| 6KBI | Crystal structure of ERBB3 N418Q mutant | x-ray diffraction | A, B | NAG | — |
| 6OP9 | HER3 pseudokinase domain bound to bosutinib | x-ray diffraction | A | DB8 | — |
| 7BHE | DARPIN_D5/HER3 domain 4 complex, monoclinic crystals | x-ray diffraction | B, D | — | — |
| 7BHF | DARPin_D5/Her3 domain 4 complex, orthorhombic crystals | x-ray diffraction | B, D | — | 4 (best 0.56) |
| 7BHF | DARPIN_D5/HER3 domain 4 complex, orthorhombic crystals | x-ray diffraction | B, D | — | — |
| 7D85 | Crystal structure of anti-ERBB3 Fab ISU104 in complex with human ERBB3 extracellular domain 3 | x-ray diffraction | A, D | NAG | — |
| 7MN5 | Structure of the HER2/HER3/NRG1B heterodimer extracellular domain | electron microscopy | A | NAG | — |
| 7MN6 | Structure of the HER2 S310F/HER3/NRG1B heterodimer extracellular domain | electron microscopy | A | NAG | — |
| 7MN8 | Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab | electron microscopy | A | NAG | — |
| 7MN8 | Structure of the HER2/HER3/NRG1B heterodimer extracellular domain bound to trastuzumab Fab | electron microscopy | A | NAG | — |
| P21860 | AlphaFold monomer V2.0 prediction for receptor tyrosine-protein kinase erbb-3 (P21860) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7D85 chain D against the predicted model P21860: TM-score 0.99, RMSD 0.62 Å
- 7D85 chain A against the predicted model P21860: TM-score 0.99, RMSD 0.63 Å
- 3LMG chain B against the predicted model P21860: TM-score 0.98, RMSD 0.87 Å
- 3LMG chain B against the predicted model P21860: TM-score 0.98, RMSD 0.87 Å
- 3LMG chain A against the predicted model P21860: TM-score 0.98, RMSD 0.95 Å
- 3LMG chain A against the predicted model P21860: TM-score 0.98, RMSD 0.95 Å
- 6OP9 chain A against the predicted model P21860: TM-score 0.97, RMSD 1.16 Å
- 7BHF chain D against the predicted model P21860: TM-score 0.97, RMSD 0.74 Å
- 7BHF chain D against the predicted model P21860: TM-score 0.97, RMSD 0.74 Å
- 7BHE chain D against the predicted model P21860: TM-score 0.97, RMSD 0.75 Å
Elsewhere
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