MolNFT v2 · #186078 · protein + DNA

Structure of HIV-1 Reverse Transcriptase in complex with DNA, dCTP, and CA(2+) ion

7LRM: “Structure of HIV-1 Reverse Transcriptase in complex with DNA, dCTP, and CA(2+) ion”. X-ray diffraction at 3.14, 5 ligands (DCP, GLC, FRU). MolNFT v2 #186078 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LRM
Type: protein + DNA
Length: 2,001 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.14
Source: Human immunodeficiency virus type 1; SYNTHETIC CONSTRUCT
UniProt: P03366
Ligands: DCP, GLC, FRU, CA, SO4

Structure

x-ray diffraction · resolution 3.14 · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	—	protein	553	—	P03366
B	—	protein	415	—	P03366
D	—	protein	410	—	P03366
F, E	—	dna	35	—	—

Ligands and binding sites

DCP · 2'-deoxycytidine-5'-triphosphate · ligand · 2 copies · chains A, E, C, F
GLC · alpha-D-glucopyranose · sugar · 2 copies · chains B, D
FRU · beta-D-fructofuranose · sugar · 2 copies · chains B, D
CA · Calcium ion · metal · 2 copies · chains A, C
SO4 · Sulfate ion · ion · 2 copies · chains A, C
GOL · Glycerol · additive · 12 copies · chains A, B, C, D, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7LRM · Structure of HIV-1 reverse transcriptase in complex with DNA, dctp, and CA(2+) ion · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03366
Elsewhere: RCSB PDB 7LRM · PDBe 7LRM · UniProt P03366

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