MolNFT v2 · #183848 · protein

EGFR kinase (T790M/V948R) in complex with AZ5104

7JXL: “EGFR kinase (T790M/V948R) in complex with AZ5104”. X-ray diffraction at 2.4, 1 ligand (VO7). MolNFT v2 #183848 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7JXL
Type: protein
Length: 1,163 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.4
Source: Homo sapiens
UniProt: P00533
Ligands: VO7

Structure

x-ray diffraction · resolution 2.4 · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	—	protein	292	—	P00533
A	—	protein	294	—	P00533
C	—	protein	292	—	P00533
B	—	protein	285	—	P00533

Ligands and binding sites

VO7 · N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl) propanamide · ligand · 4 copies · chains D, A, C, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7JXL · EGFR kinase (T790M/V948R) in complex with AZ5104 · the same entry in another collection · chain D against D, TM-score 1.00
P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain B against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00533
Elsewhere: RCSB PDB 7JXL · PDBe 7JXL · UniProt P00533

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