MolNFT v2 · #181679 · protein
ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z100642432
7G8A: “ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z100642432”. X-ray diffraction at 1.5, 1 ligand (WJ7). MolNFT v2 #181679 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7G8A
- Type
- protein
- Length
- 424 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.5
- Source
- Homo sapiens
- UniProt
- P61586, Q92974
- Ligands
- WJ7
Structure
x-ray diffraction · resolution 1.5 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 179 | — | P61586 |
| B | — | protein | 245 | — | Q92974 |
Ligands and binding sites
- WJ7 · 2-bromo-4-fluoro-N,N-dimethylbenzamide · ligand · chains A, B
- FMT · Formic acid · additive · 15 copies · chains A, B
- DMS · Dimethyl sulfoxide · additive · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- Q92974 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 2 (Q92974) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P61586 · AlphaFold monomer V2.0 prediction for transforming protein rhoa (P61586) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61586
- Every structure of UniProt Q92974
- Elsewhere: RCSB PDB 7G8A · PDBe 7G8A · UniProt P61586 · UniProt Q92974
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