UniProt Q92974
Rho guanine nucleotide exchange factor 2 (Q92974)
Rho guanine nucleotide exchange factor 2 (UniProt Q92974): 33 experimental structures and 1 predicted model on GenesisL1, 20 ligands bound, 136 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q92974
- Protein
- Rho guanine nucleotide exchange factor 2
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 20
- Pockets
- 136 · 29 records with a druggable one
Structures
34 records of Q92974 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5EFX | Crystal structure of Rho GTPase regulator | x-ray diffraction | A | — | — |
| 5EFX | Crystal structure of rho GTPase regulator | x-ray diffraction | A | — | — |
| 7G82 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1079512010 | x-ray diffraction | B | UWS | 4 (best 0.67) |
| 7G83 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z108545814 | x-ray diffraction | B | — | 4 (best 0.68) |
| 7G84 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1102357527 | x-ray diffraction | B | — | 5 (best 0.68) |
| 7G86 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1137725943 | x-ray diffraction | B | YXB | 5 (best 0.66) |
| 7G87 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1148165337 | x-ray diffraction | B | — | 5 (best 0.67) |
| 7G8A | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z100642432 | x-ray diffraction | B | WJ7 | — |
| 7G8B | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z100643660 | x-ray diffraction | B | LFO | 4 (best 0.66) |
| 7G8D | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z104474228 | x-ray diffraction | B | 60P | 5 (best 0.67) |
| 7G8K | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1217131798 | x-ray diffraction | B | YZK | 4 (best 0.66) |
| 7G8Q | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1269220427 | x-ray diffraction | B | Z2Z | 5 (best 0.67) |
| 7G8R | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1270087714 | x-ray diffraction | B | — | 5 (best 0.67) |
| 7G8S | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1270393711 | x-ray diffraction | B | Z5C | 5 (best 0.67) |
| 7G8U | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z131833926 | x-ray diffraction | B | Z3O | 4 (best 0.67) |
| 7G8V | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z133716556 | x-ray diffraction | B | — | 5 (best 0.67) |
| 7G8X | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1416571195 | x-ray diffraction | B | — | 4 (best 0.68) |
| 7G8Y | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1449748885 | x-ray diffraction | B | — | 4 (best 0.67) |
| 7G90 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1509195674 | x-ray diffraction | B | — | 5 (best 0.66) |
| 7G94 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1575337975 | x-ray diffraction | B | ZC9 | 4 (best 0.68) |
| 7G95 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z165170770 | x-ray diffraction | B | W0Y | 4 (best 0.67) |
| 7G96 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1203730981 | x-ray diffraction | B | ZCI | 3 (best 0.68) |
| 7G97 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z57899718 | x-ray diffraction | B | — | 5 (best 0.63) |
| 7G98 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z4605084898 | x-ray diffraction | B | ZDL | 6 (best 0.59) |
| 7G99 | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102102-001 | x-ray diffraction | B | ZE9 | 6 (best 0.59) |
| 7G9A | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102113-001 | x-ray diffraction | B | ZEK | 5 (best 0.65) |
| 7G9B | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102116-001 | x-ray diffraction | B | ZG0 | 5 (best 0.66) |
| 7G9D | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102179-001 | x-ray diffraction | B | T7Y | 4 (best 0.66) |
| 7G9E | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102197-001 | x-ray diffraction | B | ZG6 | 5 (best 0.66) |
| 7G9G | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102236-001 | x-ray diffraction | B | ZGK | 5 (best 0.67) |
| 7G9I | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102253-001 | x-ray diffraction | B | — | 5 (best 0.67) |
| 7G9J | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102281-001 | x-ray diffraction | B | ZGX | 6 (best 0.66) |
| 8BNT | The DH domain of ARHGEF2 bound to RhoA | x-ray diffraction | B | — | — |
| Q92974 | AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 2 (Q92974) | predicted | A | — | — |
Ligands
- 60P · 3-methylthiophene-2-carboxylic acid · in 1 record
- LFO · N,1-dimethyl-1H-indole-3-carboxamide · in 1 record
- T7Y · N-[3-(2-oxopyrrolidin-1-yl)phenyl]acetamide · in 1 record
- UWS · 6-methyl-2-[(3-methyl-1,2-oxazol-5-yl)methyl]pyridazin-3(2H)-one · in 1 record
- W0Y · N-methyl-4-sulfamoylbenzamide · in 1 record
- WJ7 · 2-bromo-4-fluoro-N,N-dimethylbenzamide · in 1 record
- YXB · N-[(1H-indol-4-yl)methyl]ethanamine · in 1 record
- YZK · (3M)-3-(2-methyl-1H-imidazol-1-yl)pyridine · in 1 record
- Z2Z · 8-(methanesulfonyl)quinoline · in 1 record
- Z3O · (3S)-3-{[(4R)-4-methyl-3,4-dihydropyridin-1(2H)-yl]methyl}-3H-indole · in 1 record
- Z5C · 5-(methoxymethyl)-1,2-oxazole-3-carboxamide · in 1 record
- ZC9 · (2P)-5-fluoro-2-(1H-pyrazol-5-yl)pyridine · in 1 record
- ZCI · 2-bromo-1H-imidazole · in 1 record
- ZDL · 1,3-dimethylimidazolidine · in 1 record
- ZE9 · 1-[(3R,5R)-5-(furan-2-yl)-3-(5-methylfuran-2-yl)pyrazolidin-1-yl]ethan-1-one · in 1 record
- ZEK · 3-acetamido-N-methylbenzamide · in 1 record
- ZG0 · N-(3-methylphenyl)acetamide · in 1 record
- ZG6 · N-(3-methyl-1,2-oxazol-5-yl)acetamide · in 1 record
- ZGK · N-(2-methoxyphenyl)acetamide · in 1 record
- ZGX · 1-(3,4-dihydropyrazin-1(2H)-yl)ethan-1-one · in 1 record
Experiment against prediction
- 7G98 chain B against the predicted model Q92974: TM-score 0.98, RMSD 1.03 Å
- 7G9A chain B against the predicted model Q92974: TM-score 0.97, RMSD 1.19 Å
- 7G9D chain B against the predicted model Q92974: TM-score 0.97, RMSD 1.20 Å
- 7G8D chain B against the predicted model Q92974: TM-score 0.97, RMSD 1.14 Å
- 7G9B chain B against the predicted model Q92974: TM-score 0.97, RMSD 1.18 Å
- 7G9G chain B against the predicted model Q92974: TM-score 0.97, RMSD 1.25 Å
- 7G97 chain B against the predicted model Q92974: TM-score 0.97, RMSD 1.15 Å
- 5EFX chain A against the predicted model Q92974: TM-score 0.96, RMSD 1.06 Å
- 5EFX chain A against the predicted model Q92974: TM-score 0.96, RMSD 1.06 Å
- 7G90 chain B against the predicted model Q92974: TM-score 0.96, RMSD 1.47 Å
Elsewhere
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