MolNFT v2 · #180060 · protein
GDP-bound KRAS G12D in complex with TH-Z835
7EWB: “GDP-bound KRAS G12D in complex with TH-Z835”. X-ray diffraction at 1.99, 4 ligands (05I, GNP, GDP). MolNFT v2 #180060 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EWB
- Type
- protein
- Length
- 507 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.99
- Source
- Homo sapiens
- UniProt
- P01116
- Ligands
- 05I, GNP, GDP, MG
Structure
x-ray diffraction · resolution 1.99 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | — | protein | 169 | — | P01116 |
Ligands and binding sites
- 05I · 4-[(1~{S},5~{R})-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(8-methylnaphthalen-1-yl)-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-d]pyrimidine · ligand · 3 copies · chains A, B, C
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · 2 copies · chains B, C
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7EWB · GDP-bound KRAS G12D in complex with th-Z835 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01116
- Elsewhere: RCSB PDB 7EWB · PDBe 7EWB · UniProt P01116
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