Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC

Structure

x-ray diffraction · resolution 4.31 · 5 distinct chains.

Ligands and binding sites

• QWP · mithramycin · ligand · 2 copies · chains A, B, D, C
• MG · Magnesium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6VGG · Crystal structure of the DNA binding domains of human transcription factor erg, human… · the same entry in another collection · chain B against B, TM-score 1.00
• Q13950 · AlphaFold monomer V2.0 prediction for runt-related transcription factor 2 (Q13950) · a predicted model of the same protein · chain D against A, TM-score 0.97
• P11308 · AlphaFold monomer V2.0 prediction for transcriptional regulator erg (P11308) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P11308
• Every structure of UniProt Q13950
• Every structure of UniProt Q13951
• Elsewhere: RCSB PDB 6VGG · PDBe 6VGG · UniProt P11308 · UniProt Q13950 · UniProt Q13951