MolNFT v2 · #163212 · protein
The Transcriptional Regulator PrfA-L140F mutant from Listeria Monocytogenes
6QW1 · Listeriolysin positive regulatory factor A: “The Transcriptional Regulator PrfA-L140F mutant from Listeria Monocytogenes”. X-ray diffraction at 1.844, 1 ligand (NA), 2 pockets (best druggability 0.83). MolNFT v2 #163212 on…
- PDB
- 6QW1
- Type
- protein
- Length
- 466 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.844
- Source
- Listeria monocytogenes
- Molecule
- Listeriolysin positive regulatory factor A
- UniProt
- Q4TVQ0
- Ligands
- NA
- Pockets
- 2 · best druggability 0.83
Structure
x-ray diffraction · resolution 1.844 · 2 distinct chains · 47% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Listeriolysin positive regulatory factor A | protein | 230 | 47% helix, 27% strand | Q4TVQ0 |
| B | Listeriolysin positive regulatory factor A | protein | 236 | 46% helix, 25% strand | Q4TVQ0 |
Ligands and binding sites
- NA · Sodium ion · metal · 3 copies · chains A, B
- IPA · Isopropyl alcohol · additive · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1020 | 0.83 | 0.84 | 100 | IPA |
| 2 | 490 | 0.78 | 0.85 | 49 | IPA |
Interfaces
1 interface between chains.
- A–B · 2171 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6QW1 · The transcriptional regulator prfa-L140F mutant from listeria monocytogenes · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4TVQ0
- Elsewhere: RCSB PDB 6QW1 · PDBe 6QW1 · UniProt Q4TVQ0
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