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The Transcriptional Regulator PrfA-L140F mutant from Listeria Monocytogenes

Analyse The Transcriptional Regulator PrfA-L140F mutant from Listeria Monocytogenes in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6QW1
Type: protein
Length: 466 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.844
Source: Listeria monocytogenes
Molecule: Listeriolysin positive regulatory factor A
UniProt: Q4TVQ0
Ligands: NA
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · resolution 1.844 · 2 distinct chains · 47% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Listeriolysin positive regulatory factor A	protein	230	47% helix, 27% strand	Q4TVQ0
B	Listeriolysin positive regulatory factor A	protein	236	46% helix, 25% strand	Q4TVQ0

Ligands and binding sites

NA · Sodium ion · metal · 3 copies · chains A, B
IPA · Isopropyl alcohol · additive · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1020	0.83	0.84	100	IPA
2	490	0.78	0.85	49	IPA

Interfaces

1 interface between chains.

A–B · 2171 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6QW1 · The transcriptional regulator prfa-L140F mutant from listeria monocytogenes · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4TVQ0
Elsewhere: RCSB PDB 6QW1 · PDBe 6QW1 · UniProt Q4TVQ0

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