MolNFT v2 · #160014 · protein

Crystal structure of STING CTT in complex with TBK1

6O8C: “Crystal structure of STING CTT in complex with TBK1”. X-ray diffraction at 3.17, 1 ligand (BX7). MolNFT v2 #160014 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6O8C
Type: protein
Length: 1,305 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.17
Source: Homo sapiens; Mus musculus
UniProt: Q9WUN2, Q86WV6
Ligands: BX7

Structure

x-ray diffraction · resolution 3.17 · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	636	—	Q9WUN2
B	—	protein	643	—	Q9WUN2
D	—	protein	14	—	Q86WV6
E	—	protein	12	—	Q86WV6

Ligands and binding sites

BX7 · N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl) amino]propyl}amino)pyrimidin-2-yl]amino}phenyl) pyrrolidine-1-carboxamide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6O8C · Crystal structure of sting ctt in complex with TBK1 · the same entry in another collection · chain E against E, TM-score 1.00
Q9WUN2 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase TBK1 (Q9WUN2) · a predicted model of the same protein · chain A against A, TM-score 0.94
Q86WV6 · AlphaFold monomer V2.0 prediction for stimulator of interferon genes protein (Q86WV6) · a predicted model of the same protein · chain E against A, TM-score 0.33

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WUN2
Every structure of UniProt Q86WV6
Elsewhere: RCSB PDB 6O8C · PDBe 6O8C · UniProt Q9WUN2 · UniProt Q86WV6

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