MolNFT v2 · #157811 · protein
Structural basis of coreceptor recognition by HIV-1 envelope spike
6MEO: “Structural basis of coreceptor recognition by HIV-1 envelope spike”. Electron microscopy at 3.9, 4 ligands (NAG, BMA, MAN). MolNFT v2 #157811 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MEO
- Type
- protein
- Length
- 887 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.9
- Source
- Homo sapiens; Human immunodeficiency virus 1
- UniProt
- Q70145, P01730, P51681
- Ligands
- NAG, BMA, MAN, A2G
Structure
electron microscopy · resolution 3.9 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | — | protein | 398 | — | Q70145 |
| A | — | protein | 176 | — | P01730 |
| B | — | protein | 313 | — | P51681 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 25 copies · chains G
- BMA · beta-D-mannopyranose · sugar · 4 copies
- MAN · alpha-D-mannopyranose · sugar · 2 copies · chains G
- A2G · 2-acetamido-2-deoxy-alpha-D-galactopyranose · sugar · chains G, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6MEO · Structural basis of coreceptor recognition by HIV-1 envelope spike · the same entry in another collection · chain A against A, TM-score 1.00
- P01730 · AlphaFold monomer V2.0 prediction for T-cell surface glycoprotein CD4 (P01730) · a predicted model of the same protein · chain A against A, TM-score 0.94
- P51681 · AlphaFold monomer V2.0 prediction for C-C chemokine receptor type 5 (P51681) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q70145
- Every structure of UniProt P01730
- Every structure of UniProt P51681
- Elsewhere: RCSB PDB 6MEO · PDBe 6MEO · UniProt Q70145 · UniProt P01730 · UniProt P51681
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