UniProt P01730
T-cell surface glycoprotein CD4 (P01730)
T-cell surface glycoprotein CD4 (UniProt P01730): 128 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01730
- Protein
- T-cell surface glycoprotein CD4
- Experimental structures
- 128
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 42 · 6 records with a druggable one
Structures
129 records of P01730 in the MolNFT archive: 128 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CDH | Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices | x-ray diffraction | A | — | — |
| 1CDH | Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices | x-ray diffraction | A | — | — |
| 1CDI | Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices | x-ray diffraction | A | — | — |
| 1CDI | Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices | x-ray diffraction | A | — | — |
| 1CDJ | Structure of T-cell surface glycoprotein CD4 | x-ray diffraction | A | — | — |
| 1CDJ | Structure of T-cell surface glycoprotein CD4 | x-ray diffraction | A | — | — |
| 1CDU | Structure of T-cell surface glycoprotein CD4 mutant with phe 43 replaced by val | x-ray diffraction | A | — | — |
| 1CDU | Structure of T-cell surface glycoprotein CD4 mutant with phe 43 replaced by val | x-ray diffraction | A | — | — |
| 1CDY | Structure of T-cell surface glycoprotein CD4 mutant with gly 47 replaced by ser | x-ray diffraction | A | — | — |
| 1CDY | Structure of T-cell surface glycoprotein CD4 mutant with gly 47 replaced by ser | x-ray diffraction | A | — | — |
| 1G9M | HIV-1 HXBC2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | C | — | — |
| 1G9M | HIV-1 HXBC2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | C | — | — |
| 1G9N | HIV-1 YU2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | C | — | — |
| 1G9N | HIV-1 YU2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | C | — | — |
| 1GC1 | HIV-1 GP120 core complexed with CD4 and a neutralizing human antibody | x-ray diffraction | C | — | — |
| 1GC1 | HIV-1 GP120 core complexed with CD4 and a neutralizing human antibody | x-ray diffraction | C | — | — |
| 1JL4 | Crystal structure of the human CD4 N-terminal two domain fragment complexed to a class II MHC… | x-ray diffraction | D | — | — |
| 1JL4 | Crystal structure of the human CD4 N-terminal two domain fragment complexed to a class II MHC… | x-ray diffraction | D | — | — |
| 1Q68 | Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase… | solution nmr | A | — | — |
| 1Q68 | Solution structure of T-cell surface glycoprotein CD4 and proto- oncogene tyrosine-protein kinase… | solution nmr | A | — | — |
| 1RZJ | HIV-1 HXBC2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | C | — | — |
| 1RZJ | HIV-1 HXBC2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | C | — | — |
| 1RZK | HIV-1 YU2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | C | — | — |
| 1RZK | HIV-1 YU2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | C | — | — |
| 1WBR | Solution structure of the human CD4 (403-419) receptor peptide, NMR, 32 structures | solution nmr | A | — | — |
| 1WBR | Solution structure of the human CD4 (403-419) receptor peptide, NMR, 32 structures | solution nmr | A | — | — |
| 1WIO | Structure of T-cell surface glycoprotein CD4, tetragonal crystal form | x-ray diffraction | A, B | — | — |
| 1WIO | Structure of T-cell surface glycoprotein CD4, tetragonal crystal form | x-ray diffraction | A, B | — | — |
| 1WIP | Structure of T-cell surface glycoprotein CD4, monoclinic crystal form | x-ray diffraction | A, B | — | — |
| 1WIP | Structure of T-cell surface glycoprotein CD4, monoclinic crystal form | x-ray diffraction | A, B | — | — |
| 1WIQ | Structure of T-cell surface glycoprotein CD4, trigonal crystal form | x-ray diffraction | A, B | — | — |
| 1WIQ | Structure of T-cell surface glycoprotein CD4, trigonal crystal form | x-ray diffraction | A, B | — | — |
| 2B4C | Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3)… | x-ray diffraction | C | — | — |
| 2B4C | Crystal structure of HIV-1 jr-fl GP120 core protein containing the third variable region (V3)… | x-ray diffraction | C | — | — |
| 2KLU | NMR structure of the transmembrane and cytoplasmic domains of human CD4 | solution nmr | A | — | — |
| 2KLU | NMR structure of the transmembrane and cytoplasmic domains of human CD4 | solution nmr | A | — | — |
| 2NXY | HIV-1 gp120 Envelope Glycoprotein(S334A) Complexed with CD4 and Antibody 17b | x-ray diffraction | B | — | — |
| 2NXY | HIV-1 GP120 envelope GLYCOPROTEIN(S334A) complexed with CD4 and antibody 17B | x-ray diffraction | B | — | — |
| 2NXZ | HIV-1 gp120 Envelope Glycoprotein (T257S, S334A, S375W) Complexed with CD4 and Antibody 17b | x-ray diffraction | B | — | — |
| 2NXZ | HIV-1 GP120 envelope glycoprotein (T257S, S334A, S375W) complexed with CD4 and antibody 17B | x-ray diffraction | B | — | — |
| 2NY0 | HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, T257S, V275C, S334A, S375W, A433M) Complexed with… | x-ray diffraction | B | — | — |
| 2NY0 | HIV-1 GP120 envelope glycoprotein (M95W, W96C, T257S, V275C, S334A, S375W, A433M) complexed with… | x-ray diffraction | B | — | — |
| 2NY1 | HIV-1 gp120 Envelope Glycoprotein (I109C, T257S, S334A, S375W, Q428C) Complexed with CD4 and… | x-ray diffraction | B | — | — |
| 2NY1 | HIV-1 GP120 envelope glycoprotein (I109C, T257S, S334A, S375W, Q428C) complexed with CD4 and… | x-ray diffraction | B | — | — |
| 2NY2 | HIV-1 gp120 Envelope Glycoprotein (T123C, T257S, S334A, S375W, G431C) Complexed with CD4 and… | x-ray diffraction | B | — | — |
| 2NY2 | HIV-1 GP120 envelope glycoprotein (T123C, T257S, S334A, S375W, G431C) complexed with CD4 and… | x-ray diffraction | B | — | — |
| 2NY3 | HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E267C, S334A, S375W) Complexed with CD4 and… | x-ray diffraction | B | — | — |
| 2NY3 | HIV-1 GP120 envelope glycoprotein (K231C, T257S, E267C, S334A, S375W) complexed with CD4 and… | x-ray diffraction | B | — | — |
| 2NY4 | HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E268C, S334A, S375W) Complexed with CD4 and… | x-ray diffraction | B | — | — |
| 2NY4 | HIV-1 GP120 envelope glycoprotein (K231C, T257S, E268C, S334A, S375W) complexed with CD4 and… | x-ray diffraction | B | — | — |
| 2NY5 | HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M)… | x-ray diffraction | C | — | — |
| 2NY5 | HIV-1 GP120 envelope glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M)… | x-ray diffraction | C | — | — |
| 2NY6 | HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T123C, T257S, V275C,S334A, S375W, Q428C… | x-ray diffraction | B | — | — |
| 2NY6 | HIV-1 GP120 envelope glycoprotein (M95W, W96C, I109C, T123C, T257S, V275C,S334A, S375W, Q428C… | x-ray diffraction | B | — | — |
| 2QAD | Structure of tyrosine-sulfated 412d antibody complexed with HIV-1 YU2 gp120 and CD4 | x-ray diffraction | B, F | — | — |
| 2QAD | Structure of tyrosine-sulfated 412D antibody complexed with HIV-1 YU2 GP120 and CD4 | x-ray diffraction | B, F | — | — |
| 3B71 | CD4 endocytosis motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion… | x-ray diffraction | D, E, F | — | — |
| 3B71 | CD4 endocytosis motif bound to the focal adhesion targeting (fat) domain of the focal adhesion… | x-ray diffraction | D, E, F | — | — |
| 3CD4 | Refinement and analysis of the first two domains of human CD4 | x-ray diffraction | A | — | — |
| 3CD4 | Refinement and analysis of the first two domains of human CD4 | x-ray diffraction | A | — | — |
69 records more on the page itself.
Ligands
Experiment against prediction
- 4R2G chain L against the predicted model P01730: TM-score 0.98, RMSD 0.73 Å
- 4R2G chain L against the predicted model P01730: TM-score 0.98, RMSD 0.73 Å
- 1CDY chain A against the predicted model P01730: TM-score 0.98, RMSD 0.80 Å
- 1CDY chain A against the predicted model P01730: TM-score 0.98, RMSD 0.80 Å
- 6OPP chain F against the predicted model P01730: TM-score 0.98, RMSD 0.54 Å
- 4RQS chain B against the predicted model P01730: TM-score 0.98, RMSD 0.87 Å
- 4RQS chain B against the predicted model P01730: TM-score 0.98, RMSD 0.87 Å
- 2NY1 chain B against the predicted model P01730: TM-score 0.98, RMSD 0.79 Å
- 2NY1 chain B against the predicted model P01730: TM-score 0.98, RMSD 0.79 Å
- 3S5L chain G against the predicted model P01730: TM-score 0.98, RMSD 0.81 Å
Elsewhere
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