MolNFT v2 · #155971 · protein

Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys mutant

6KRK: “Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys mutant”. X-ray diffraction at 1.8, 20 pockets (best druggability 0.58). MolNFT v2 #155971 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6KRK
Type: protein
Length: 2,440 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.8
Source: Aeropyrum pernix K1
Molecule: Peroxiredoxin
EC: 1.11.1.15
UniProt: Q9Y9L0
Pockets: 20 · best druggability 0.58

Structure

x-ray diffraction · resolution 1.8 · 1 distinct chain · 34% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J	Peroxiredoxin (EC 1.11.1.15)	protein	244	34% helix, 23% strand	Q9Y9L0

Ligands and binding sites

CIT · Citric acid · additive · 10 copies · chains A, B, J, D, C, H, E, F, G, I

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	325	0.58	0.76	41	CIT
2	281	0.56	0.77	46	CIT
3	292	0.56	0.76	48	CIT
4	296	0.56	0.76	41	CIT
5	281	0.56	0.76	42	CIT

Interfaces

20 interfaces between chains.

G–H · 3619 Å² buried · 55 hydrogen bonds · protein-protein
C–D · 3599 Å² buried · 55 hydrogen bonds · protein-protein
A–B · 3579 Å² buried · 51 hydrogen bonds · protein-protein
E–F · 3549 Å² buried · 57 hydrogen bonds · protein-protein
I–J · 3544 Å² buried · 55 hydrogen bonds · protein-protein

Compared structures

6KRK · Peroxiredoxin from aeropyrum pernix K1 (apprx) 0CYS mutant · the same entry in another collection · chain J against J, TM-score 1.00
Q9Y9L0 · AlphaFold monomer V2.0 prediction for peroxiredoxin (Q9Y9L0) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y9L0
Elsewhere: RCSB PDB 6KRK · PDBe 6KRK · UniProt Q9Y9L0

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