UniProt Q9Y9L0

Peroxiredoxin (Q9Y9L0)

Peroxiredoxin (UniProt Q9Y9L0), EC 1.11.1.15, 1.11.1.24: 42 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 101 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…

UniProt: Q9Y9L0
Protein: Peroxiredoxin
EC: 1.11.1.15, 1.11.1.24
Experimental structures: 42
Predicted models: 1
Ligands: 2
Pockets: 101 · 5 records with a druggable one

Structures

43 records of Q9Y9L0 in the MolNFT archive: 42 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1X0R	Thioredoxin Peroxidase from Aeropyrum pernix K1	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
1X0R	Thioredoxin peroxidase from aeropyrum pernix K1	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2CV4	Crystal Structure of an Archaeal Peroxiredoxin from the Aerobic Hyperthermophilic Crenarchaeon…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2CV4	Crystal structure of an archaeal peroxiredoxin from the aerobic hyperthermophilic crenarchaeon…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2E2G	Crystal structure of archaeal peroxiredoxin, thioredoxin peroxidase from Aeropyrum pernix K1…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2E2G	Crystal structure of archaeal peroxiredoxin, thioredoxin peroxidase from aeropyrum pernix K1…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2E2M	Crystal structure of archaeal peroxiredoxin, thioredoxin peroxidase from Aeropyrum pernix K1…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2E2M	Crystal structure of archaeal peroxiredoxin, thioredoxin peroxidase from aeropyrum pernix K1…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2NVL	Crystal structure of archaeal peroxiredoxin, thioredoxin peroxidase from Aeropyrum pernix K1…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2NVL	Crystal structure of archaeal peroxiredoxin, thioredoxin peroxidase from aeropyrum pernix K1…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2ZCT	Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2ZCT	Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
3A2V	Peroxiredoxin (C207S) from Aeropyrum pernix K1 complexed with hydrogen peroxide	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
3A2V	Peroxiredoxin (C207S) from aeropyrum pernix K1 complexed with hydrogen peroxide	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
3A2W	Peroxiredoxin (C50S) from Aeropytum pernix K1 (peroxide-bound form)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
3A2W	Peroxiredoxin (C50S) from aeropytum pernix K1 (peroxide-bound form)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
3A2X	Peroxiredoxin (C50S) from Aeropyrum pernix K1 (acetate-bound form)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
3A2X	Peroxiredoxin (C50S) from aeropyrum pernix K1 (acetate-bound form)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
3A5W	Peroxiredoxin (wild type) from Aeropyrum pernix K1 (reduced form)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
3A5W	Peroxiredoxin (wild type) from aeropyrum pernix K1 (reduced form)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
5XBS	Peroxiredoxin from Aeropyrum pernix (6m mutant)	x-ray diffraction	A, B, C, D	—	—
5XBS	Peroxiredoxin from aeropyrum pernix (6M mutant)	x-ray diffraction	A, B, C, D	—	—
6KRK	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
6KRK	Peroxiredoxin from aeropyrum pernix K1 (apprx) 0CYS mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
6KRM	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys F46A mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
6KRM	Peroxiredoxin from aeropyrum pernix K1 (apprx) 0CYS F46A mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
6KRP	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys W88A mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	20 (best 0.57)
6KRP	Peroxiredoxin from aeropyrum pernix K1 (apprx) 0CYS W88A mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
6KRQ	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys F80A mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
6KRQ	Peroxiredoxin from aeropyrum pernix K1 (apprx) 0CYS F80A mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
6KRR	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys W210A mutant	x-ray diffraction	A, B, C, D	—	—
6KRR	Peroxiredoxin from aeropyrum pernix K1 (apprx) 0CYS W210A mutant	x-ray diffraction	A, B, C, D	—	—
6KRS	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys W211A mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
6KRS	Peroxiredoxin from aeropyrum pernix K1 (apprx) 0CYS W211A mutant	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
7C87	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) C50S/F80C/C207S/C213S mutant (ApPrx*F80C)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	20 (best 0.62)
7C87	Peroxiredoxin from aeropyrum pernix K1 (apprx) C50S/F80C/C207S/C213S mutant (APPRX*F80C)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
7C89	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) C50S/F80C/C207S/C213S mutant modified with…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	FL0	20 (best 0.62)
7C89	Peroxiredoxin from aeropyrum pernix K1 (apprx) C50S/F80C/C207S/C213S mutant modified with…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	FL0	—
7C8A	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) C50S/F80C/C207S/C213S mutant modified with…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	FL3	20 (best 0.61)
7C8A	Peroxiredoxin from aeropyrum pernix K1 (apprx) C50S/F80C/C207S/C213S mutant modified with…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	FL3	—
7CQJ	Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) C50S/K84A/C207S/C213S mutant (ApPrx*K84A)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L	—	20 (best 0.65)
7CQJ	Peroxiredoxin from aeropyrum pernix K1 (apprx) C50S/K84A/C207S/C213S mutant (APPRX*K84A)	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L	—	—
Q9Y9L0	AlphaFold monomer V2.0 prediction for peroxiredoxin (Q9Y9L0)	predicted	A	—	1 (best 0.33)

Ligands

FL0 · 2-bromanyl-1-phenyl-ethanone · in 2 records
FL3 · 1-naphthalen-2-ylethanone · in 2 records

Experiment against prediction

3A2V chain B against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.24 Å
3A2V chain B against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.24 Å
6KRK chain A against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.25 Å
6KRK chain A against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.25 Å
6KRM chain A against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.26 Å
6KRM chain A against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.26 Å
3A2X chain B against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.26 Å
3A2X chain B against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.26 Å
3A2V chain D against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.27 Å
3A2V chain D against the predicted model Q9Y9L0: TM-score 1.00, RMSD 0.27 Å

Elsewhere

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