MolNFT v2 · #155866 · protein

THRb mutation with a novel agonist

6KNV: “THRb mutation with a novel agonist”. X-ray diffraction at 2.8, 1 ligand (8HO). MolNFT v2 #155866 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6KNV
Type: protein
Length: 246 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.8
Source: Homo sapiens
UniProt: P10828, Q15596
Ligands: 8HO

Structure

x-ray diffraction · resolution 2.8 · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	235	—	P10828
C	—	protein	11	—	Q15596

Ligands and binding sites

8HO · 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl) carbonylamino]ethanoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6KNV · Thrb mutation with a novel agonist · the same entry in another collection · chain A against A, TM-score 1.00
P10828 · AlphaFold monomer V2.0 prediction for thyroid hormone receptor beta (P10828) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10828
Every structure of UniProt Q15596
Elsewhere: RCSB PDB 6KNV · PDBe 6KNV · UniProt P10828 · UniProt Q15596

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