MolNFT v2 · #153588 · protein
Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6
6IN1: “Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6”. X-ray diffraction at 1.5, 3 ligands (LOC, O4B, NA). MolNFT v2 #153588 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6IN1
- Type
- protein
- Length
- 128 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.5
- Source
- Homo sapiens
- UniProt
- O60885
- Ligands
- LOC, O4B, NA
Structure
x-ray diffraction · resolution 1.5 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 128 | — | O60885 |
Ligands and binding sites
- LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide · ligand · chains A
- O4B · 1,4,7,10,13,16-hexaoxacyclooctadecane · ligand · chains A
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6IN1 · Crystal structure of the first bromodomain of BRD4 in complex with 18- crown-6 · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 6IN1 · PDBe 6IN1 · UniProt O60885
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