MolNFT v2 · #152994 · protein
Crystal structure of the disease-causing G194C mutant of the human dihydrolipoamide dehydrogenase
6I4P: “Crystal structure of the disease-causing G194C mutant of the human dihydrolipoamide dehydrogenase”. X-ray diffraction at 1.6, 2 ligands (FAD, SO4). MolNFT v2 #152994 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6I4P
- Type
- protein
- Length
- 953 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.6
- Source
- Homo sapiens
- UniProt
- P09622
- Ligands
- FAD, SO4
Structure
x-ray diffraction · resolution 1.6 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 472 | — | P09622 |
| B | — | protein | 481 | — | P09622 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 9 copies · chains A, B
- BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6I4P · Crystal structure of the disease-causing G194C mutant of the human dihydrolipoamide… · the same entry in another collection · chain A against A, TM-score 1.00
- P09622 · AlphaFold monomer V2.0 prediction for dihydrolipoyl dehydrogenase, mitochondrial (P09622) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09622
- Elsewhere: RCSB PDB 6I4P · PDBe 6I4P · UniProt P09622
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