UniProt P09622

Dihydrolipoyl dehydrogenase, mitochondrial (P09622)

Dihydrolipoyl dehydrogenase, mitochondrial (UniProt P09622), EC 1.8.1.4: 31 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 57 pockets. Binding sites, druggability and experiment against prediction…

UniProt: P09622
Protein: Dihydrolipoyl dehydrogenase, mitochondrial
EC: 1.8.1.4
Experimental structures: 31
Predicted models: 1
Ligands: 3
Pockets: 57 · 7 records with a druggable one

Structures

32 records of P09622 in the MolNFT archive: 31 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1ZMC	Crystal Structure of Human dihydrolipoamide dehydrogenase complexed to NAD+	x-ray diffraction	A, B, C, D, E, F, G, H	—	—
1ZMC	Crystal structure of human dihydrolipoamide dehydrogenase complexed to NAD+	x-ray diffraction	A, B, C, D, E, F, G, H	—	—
1ZMD	Crystal Structure of Human dihydrolipoamide dehydrogenase complexed to NADH	x-ray diffraction	A, B, C, D, E, F, G, H	—	—
1ZMD	Crystal structure of human dihydrolipoamide dehydrogenase complexed to NADH	x-ray diffraction	A, B, C, D, E, F, G, H	—	—
1ZY8	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
1ZY8	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2F5Z	Crystal Structure of Human Dihydrolipoamide Dehydrogenase (E3) Complexed to the E3-Binding Domain…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2F5Z	Crystal structure of human dihydrolipoamide dehydrogenase (E3) complexed to the E3-binding domain…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
3RNM	The crystal structure of the subunit binding of human dihydrolipoamide transacylase (E2b) bound to…	x-ray diffraction	A, B, C, D	—	—
3RNM	The crystal structure of the subunit binding of human dihydrolipoamide transacylase (E2B) bound to…	x-ray diffraction	A, B, C, D	—	—
5J5Z	Crystal structure of the D444V disease-causing mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD, PO4	6 (best 0.83)
5J5Z	Crystal structure of the D444V disease-causing mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	—	—
5NHG	Crystal structure of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B, C, D, E, F, G, H	FAD	—
5NHG	Crystal structure of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B, C, D, E, F, G, H	FAD	—
6HG8	Crystal structure of the R460G disease-causing mutant of the human dihydrolipoamide dehydrogenase.	x-ray diffraction	A, B	FAD, SO4	—
6HG8	Crystal structure of the R460G disease-causing mutant of the human dihydrolipoamide dehydrogenase.	x-ray diffraction	A, B	FAD, SO4	—
6I4P	Crystal structure of the disease-causing G194C mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD, SO4	—
6I4P	Crystal structure of the disease-causing G194C mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD, SO4	—
6I4Q	Crystal structure of the human dihydrolipoamide dehydrogenase at 1.75 Angstrom resolution	x-ray diffraction	A, B	FAD, SO4	6 (best 0.84)
6I4Q	Crystal structure of the human dihydrolipoamide dehydrogenase at 1.75 ångström resolution	x-ray diffraction	A, B	FAD, SO4	—
6I4R	Crystal structure of the disease-causing R460G mutant of the human dihydrolipoamide dehydrogenase…	x-ray diffraction	A, B	FAD, SO4	5 (best 0.84)
6I4R	Crystal structure of the disease-causing R460G mutant of the human dihydrolipoamide dehydrogenase…	x-ray diffraction	A, B	FAD, SO4	—
6I4S	Crystal structure of the disease-causing R447G mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD, SO4	—
6I4S	Crystal structure of the disease-causing R447G mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD, SO4	—
6I4T	Crystal structure of the disease-causing I445M mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD, SO4	—
6I4U	Crystal structure of the disease-causing G426E mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD, SO4	7 (best 0.84)
6I4U	Crystal structure of the disease-causing G426E mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD, SO4	—
6I4Z	Crystal structure of the disease-causing P453L mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B, C, D, E, F, G, H	FAD, SO4	20 (best 0.84)
6I4Z	Crystal structure of the disease-causing P453L mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B, C, D, E, F, G, H	FAD, SO4	—
7PSC	Crystal structure of the disease-causing I358T mutant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD	7 (best 0.83)
7ZYT	Crystal structure of the I318T pathogenic variant of the human dihydrolipoamide dehydrogenase	x-ray diffraction	A, B	FAD	6 (best 0.83)
P09622	AlphaFold monomer V2.0 prediction for dihydrolipoyl dehydrogenase, mitochondrial (P09622)	predicted	A	—	—

Ligands

FAD · Flavin-adenine dinucleotide · in 20 records
SO4 · Sulfate ion · in 15 records
PO4 · Phosphate ion · in 1 record

Experiment against prediction

1ZMD chain H against the predicted model P09622: TM-score 1.00, RMSD 0.31 Å
1ZMD chain H against the predicted model P09622: TM-score 1.00, RMSD 0.31 Å
2F5Z chain F against the predicted model P09622: TM-score 1.00, RMSD 0.31 Å
2F5Z chain F against the predicted model P09622: TM-score 1.00, RMSD 0.31 Å
2F5Z chain H against the predicted model P09622: TM-score 1.00, RMSD 0.32 Å
2F5Z chain H against the predicted model P09622: TM-score 1.00, RMSD 0.32 Å
6I4U chain A against the predicted model P09622: TM-score 1.00, RMSD 0.32 Å
6I4U chain A against the predicted model P09622: TM-score 1.00, RMSD 0.32 Å
2F5Z chain I against the predicted model P09622: TM-score 1.00, RMSD 0.32 Å
2F5Z chain I against the predicted model P09622: TM-score 1.00, RMSD 0.32 Å

Elsewhere

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