MolNFT v2 · #151446 · protein

Structure of ArhGAP12 bound to G-Actin

6GVC: “Structure of ArhGAP12 bound to G-Actin”. X-ray diffraction at 2.6, 3 ligands (LAB, ATP, MG). MolNFT v2 #151446 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6GVC
Type: protein
Length: 2,308 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.6
Source: Mus musculus; Oryctolagus cuniculus
UniProt: P68135, Q8C0D4
Ligands: LAB, ATP, MG

Structure

x-ray diffraction · resolution 2.6 · 7 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, C	—	protein	359	—	P68135
A	—	protein	356	—	P68135
D	—	protein	356	—	P68135
R	—	protein	216	—	Q8C0D4
Q	—	protein	223	—	Q8C0D4
S	—	protein	217	—	Q8C0D4
T	—	protein	222	—	Q8C0D4

Ligands and binding sites

LAB · Latrunculin B · ligand · 4 copies · chains B, A, C, D
ATP · Adenosine-5'-triphosphate · ligand · 4 copies · chains B, A, C, D
MG · Magnesium ion · metal · 4 copies · chains B, C, D
EDO · 1,2-ethanediol · additive · 8 copies · chains B, R, A, S, C, T, D, Q

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6GVC · Structure of ARHGAP12 bound to G-actin · the same entry in another collection · chain T against T, TM-score 1.00
P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain D against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P68135
Every structure of UniProt Q8C0D4
Elsewhere: RCSB PDB 6GVC · PDBe 6GVC · UniProt P68135 · UniProt Q8C0D4

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