MolNFT v2 · #151412 · protein
CDK2/CyclinA in complex with AZD5438
6GUE: “CDK2/CyclinA in complex with AZD5438”. X-ray diffraction at 1.99, 1 ligand (FB8). MolNFT v2 #151412 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6GUE
- Type
- protein
- Length
- 1,107 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.99
- Source
- Bos taurus; Homo sapiens
- UniProt
- P24941, P30274
- Ligands
- FB8
Structure
x-ray diffraction · resolution 1.99 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 294 | — | P24941 |
| B, D | — | protein | 262 | — | P30274 |
| C | — | protein | 289 | — | P24941 |
Ligands and binding sites
- FB8 · 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine · ligand · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6GUE · CDK2/CYCLINA in complex with AZD5438 · the same entry in another collection · chain D against D, TM-score 1.00
- P30274 · AlphaFold monomer V2.0 prediction for cyclin-A2 (P30274) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P24941 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 2 (P24941) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24941
- Every structure of UniProt P30274
- Elsewhere: RCSB PDB 6GUE · PDBe 6GUE · UniProt P24941 · UniProt P30274
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