UniProt P30274
Cyclin-A2 (P30274)
Cyclin-A2 (UniProt P30274): 32 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P30274
- Protein
- Cyclin-A2
- Experimental structures
- 32
- Predicted models
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
33 records of P30274 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1VIN | Bovine cyclin A3 | x-ray diffraction | A | — | — |
| 1VIN | Bovine cyclin A3 | x-ray diffraction | A | — | — |
| 2G9X | Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271 | x-ray diffraction | B, D | — | — |
| 2G9X | Structure of thr 160 phosphorylated CDK2/CYCLIN a in complex with the inhibitor NU6271 | x-ray diffraction | B, D | — | — |
| 3BHT | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3 | x-ray diffraction | B, D | — | — |
| 3BHT | Structure of phosphorylated THR160 CDK2/CYCLIN a in complex with the inhibitor meriolin 3 | x-ray diffraction | B, D | — | — |
| 3BHU | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5 | x-ray diffraction | B, D | — | — |
| 3BHU | Structure of phosphorylated THR160 CDK2/CYCLIN a in complex with the inhibitor meriolin 5 | x-ray diffraction | B, D | — | — |
| 3BHV | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B | x-ray diffraction | B, D | — | — |
| 3BHV | Structure of phosphorylated THR160 CDK2/CYCLIN a in complex with the inhibitor variolin B | x-ray diffraction | B, D | — | — |
| 3DDP | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8 | x-ray diffraction | B, D | — | — |
| 3DDP | Structure of phosphorylated THR160 CDK2/CYCLIN a in complex with the inhibitor CR8 | x-ray diffraction | B, D | — | — |
| 3DDQ | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine | x-ray diffraction | B, D | — | — |
| 3DDQ | Structure of phosphorylated THR160 CDK2/CYCLIN a in complex with the inhibitor roscovitine | x-ray diffraction | B, D | — | — |
| 3DOG | Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1 | x-ray diffraction | B, D | — | — |
| 3DOG | Structure of thr 160 phosphorylated CDK2/CYCLIN a in complex with the inhibitor N-&-N1 | x-ray diffraction | B, D | — | — |
| 3MY5 | CDk2/cyclinA in complex with DRB | x-ray diffraction | B, D | — | — |
| 3MY5 | CDK2/CYCLINA in complex with drb | x-ray diffraction | B, D | — | — |
| 3TNW | Structure of CDK2/cyclin A in complex with CAN508 | x-ray diffraction | B, D | — | — |
| 3TNW | Structure of CDK2/CYCLIN a in complex with CAN508 | x-ray diffraction | B, D | — | — |
| 4BCO | Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B, D | — | — |
| 4BCO | Structure of CDK2 in complex with cyclin a and a 2-amino-4- heteroaryl-pyrimidine inhibitor | x-ray diffraction | B, D | — | — |
| 4BCQ | Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B, D | — | — |
| 4BCQ | Structure of CDK2 in complex with cyclin a and a 2-amino-4- heteroaryl-pyrimidine inhibitor | x-ray diffraction | B, D | — | — |
| 6GUB | CDK2/CYCLINA in complex with flavopiridol | x-ray diffraction | B, D | — | — |
| 6GUC | CDK2/CyclinA in complex with SU9516 | x-ray diffraction | B, D | — | — |
| 6GUC | CDK2/CYCLINA in complex with SU9516 | x-ray diffraction | B, D | — | — |
| 6GUE | CDK2/CyclinA in complex with AZD5438 | x-ray diffraction | B, D | — | — |
| 6GUE | CDK2/CYCLINA in complex with AZD5438 | x-ray diffraction | B, D | — | — |
| 6GUF | CDK2/CyclinA in complex with CGP74514A | x-ray diffraction | B, D | — | — |
| 6GUF | CDK2/CYCLINA in complex with CGP74514A | x-ray diffraction | B, D | — | — |
| 8ROZ | Cryo-EM structure of CDK2-cyclin A in complex with CDC25A | electron microscopy | B | — | 5 (best 0.79) |
| P30274 | AlphaFold monomer V2.0 prediction for cyclin-A2 (P30274) | predicted | A | — | — |
Experiment against prediction
- 3TNW chain D against the predicted model P30274: TM-score 1.00, RMSD 0.27 Å
- 3TNW chain D against the predicted model P30274: TM-score 1.00, RMSD 0.27 Å
- 3TNW chain B against the predicted model P30274: TM-score 1.00, RMSD 0.29 Å
- 3TNW chain B against the predicted model P30274: TM-score 1.00, RMSD 0.29 Å
- 4BCO chain D against the predicted model P30274: TM-score 1.00, RMSD 0.36 Å
- 4BCO chain D against the predicted model P30274: TM-score 1.00, RMSD 0.36 Å
- 4BCO chain B against the predicted model P30274: TM-score 1.00, RMSD 0.41 Å
- 4BCO chain B against the predicted model P30274: TM-score 1.00, RMSD 0.41 Å
- 1VIN chain A against the predicted model P30274: TM-score 1.00, RMSD 0.39 Å
- 1VIN chain A against the predicted model P30274: TM-score 1.00, RMSD 0.39 Å
Elsewhere
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