MolNFT v2 · #130172 · protein
Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cyc/Thr11Hcs
5OTV · Glucagon-like peptide 1 receptor: “Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cyc/Thr11Hcs”. X-ray diffraction at 2, 3 pockets (best druggability 0.48). MolNFT v2 #130172 on GenesisL1: 3D structure…
- PDB
- 5OTV
- Type
- protein
- Length
- 258 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- Molecule
- Glucagon-like peptide 1 receptor; Glucagon
- UniProt
- P43220, P01275
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · resolution 2 · 4 distinct chains · 37% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Glucagon-like peptide 1 receptor | protein | 100 | 27% helix, 22% strand | P43220 |
| D | Glucagon | protein | 27 | 78% helix, 0% strand | P01275 |
| A | Glucagon-like peptide 1 receptor | protein | 102 | 26% helix, 22% strand | P43220 |
| B | Glucagon | protein | 29 | 72% helix, 0% strand | P01275 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.48 | 0.77 | 22 | empty |
| 2 | 108 | 0.38 | 0.75 | 23 | empty |
| 3 | 50 | 0.29 | 0.75 | 11 | empty |
Interfaces
3 interfaces between chains.
- A–B · 564 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 529 Ų buried · 1 hydrogen bond · protein-protein
- C–A · 311 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 modified (disulfide, nonstandard).
Compared structures
- 5OTV · Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8CYC/THR11HCS · the same entry in another collection · chain D against D, TM-score 1.00
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain C against A, TM-score 0.98
- P01275 · AlphaFold monomer V2.0 prediction for pro-glucagon (P01275) · a predicted model of the same protein · chain B against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43220
- Every structure of UniProt P01275
- Elsewhere: RCSB PDB 5OTV · PDBe 5OTV · UniProt P43220 · UniProt P01275
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